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    Map** of the human insulin receptor substrate-2 gene, identification of a linked polymorphic marker and linkage analysis in families with Type II diabetes: no evidence for a major susceptibility role

    Insulin receptor substrate 2 (IRS-2) is a substrate of the insulin receptor and mediates the action of the insulin. Disruption of the IRS-2 gene in mice results in peripheral insulin resistance and relative i...

    K. Kalidas, J. Wasson, B. Glaser, J. M. Meyer, L. J. Duprat, M. F. White in Diabetologia (1998)