11 Result(s)
within
B Szende
Biomedicine
English
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Article
R-Deprenyl: Pharmacological Spectrum of its Activity
Deprenyl has been discovered by Knoll and co-workers. The R-enantiomer of deprenyl (selegiline) is a selective and irreversible inhibitor of the B-isoform of monoamine oxidase (MAO-B) enzyme. Due to its dopamine ...
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Article
Open AccessEffect of a novel somatostatin analogue combined with cytotoxic drugs on human tumour xenografts and metastasis of B16 melanoma
A novel somatostatin analogue, TT-232 (which inhibits the proliferation of various cell cultures and transplantable mouse tumours), was examined regarding its effect on human melanoma and lymphoma xenografts a...
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Article
Open AccessAntitumor effect of lysine-isopeptides
Isopeptides (ε-peptides) of lysine, with a given Mw and low polydispersity (10–400 units), were synthesized to study the relationship between their chemical structure and biological effect. The designed compou...
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Article
Open AccessAntagonists of growth hormone-releasing hormone (GH-RH) inhibit IGF-II production and growth of HT-29 human colon cancers
Insulin-like growth factors (IGFs) I and II are implicated in progression of various tumours including colorectal carcinomas. To interfere with the production of IGFs, we treated male nude mice bearing xenogra...
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Chapter
The Neuroprotective and Neuronal Rescue Effect of (-)-Deprenyl
(-)-Deprenyl treatment is able to increase the dopaminergic tone in the CNS by several mechanisms. It inhibits the normal metabolic degradation of dopamine and the metabolites formed from the drug reduce the u...
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Article
Modification of pathobiological events by potential hepatopharmacological agents
The elucidation of the pathobiological events in chronic liver diseases-such as cellular injury, cell proliferation, remodelling of extracellular matrix — has considerable importance for establishing the ratio...
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Chapter
Modification of Pathobiological Events by Potential Hepatopharmacological Agents
The elucidation of the pathobiological events in chronic liver diseases — such as cellular injury, cell proliferation, remodelling of extracellular matrix — has considerable importance for establishing the rat...
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Article
Protective effects of D-Trp6-luteinising hormone-releasing hormone microcapsules against cyclophosphamide-induced gonadotoxicity in female rats
The possible protective effect of an agonist of luteinising hormone-releasing hormone (LH-RH) against the ovarian damage caused by cyclophosphamide was investigated in rats. D-Trp6-LH-RH microcapsules were inj...
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Article
The effect of E-N-l-trimethyllysine (TML) on the humoral and cellular immune response
E-N-l-Trimethyllysine glutamate (TML) influences the humoral and cellular immune response of mice. Chronic pre- and post-treatment (100 mg/kg/day, 5 times) transitionally increased the anti-SRBC haemagglutinin t...
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Chapter
Theoretical Bases for Designing Combination Therapy with Dibromodulcitol (DBD)
From the results of clinical and experimental tumour chemotherapy it seems that no single agent seems to be able to deal effectively with most of the human tumours and reasonable therapeutic results can only b...
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Article
A Transferable “Resistance Factor” from in vitro Cultured MDMS-Resistant Yoshida Sarcoma Cells
Cells of the methylene dimethanesulphonate-(MDMS)-resistant Yoshida sarcoma cell line contain a low molecular weight “resistance factor” which is present in the culture medium of these cells and may be utilize...
