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Article
Phase 1b study of lenalidomide in combination with rituximab-CHOP (R2-CHOP) in patients with B-cell lymphoma
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Article
The expression of 16 genes related to the cell of origin and immune response predicts survival in elderly patients with diffuse large B-cell lymphoma treated with CHOP and rituximab
Gene expression profiles have been associated with clinical outcome in patients with diffuse large B-cell lymphoma (DLBCL) treated with anthracycline-containing chemotherapy. Using Affymetrix HU133A microarray...
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Article
Splenic marginal zone lymphoma proposals for a revision of diagnostic, staging and therapeutic criteria
Since the initial description of splenic marginal zone lymphoma (SMZL) in 1992, an increasing number of publications have dealt with multiple aspects of SMZL diagnosis, molecular pathogenesis and treatment. Th...
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Article
Analysis of BCL-6, CD95, PIM1, RHO/TTF and PAX5 mutations in splenic and nodal marginal zone B-cell lymphomas suggests a particular B-cell origin
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Article
Rituximab therapy in malignant lymphoma
Rituximab is the first monoclonal antibody to have been registered for the treatment of B-cell lymphomas. Randomized studies haves demonstrated its activity in follicular lymphoma (FL), mantle cell lymphoma an...
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Article
Open AccessEffect of treatment with epoetin beta on short-term tumour progression and survival in anaemic patients with cancer: a meta-analysis
To assess the early effect of epoetin beta on survival and tumour progression in anaemic patients with cancer, data were pooled from nine randomised clinical trials comparing epoetin beta with placebo or stand...
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Article
Cytogenetic analysis delineates a spectrum of chromosomal changes that can distinguish non-MALT marginal zone B-cell lymphomas among mature B-cell entities: a description of 103 cases
The purpose of this study was to document the frequency and distribution of karyotypic changes present at diagnosis in 103 non-MALT marginal zone cell lymphoma (MZL) patients. This cytogenetic analysis of a la...
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Article
FcγRIIB expression in diffuse large B-cell lymphomas does not alter the response to CHOP+rituximab (R-CHOP)
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Article
Open AccessImpact of epoetin β on quality of life in patients with malignant disease
This open-label, prospective study was conducted to compare the impact of epoetin β vs standard care on quality of life (QoL) in anaemic patients with lymphoid or solid tumour malignancies. A total of 262 anaemic...
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Article
Long-term outcome with pentostatin treatment in hairy cell leukemia patients. A French retrospective study of 238 patients
With the introduction of new drugs such as alpha-interferon (IFN) and purine analogs, the management of hairy cell leukemia (HCL) patients has changed. However, deoxycoformycin (DCF) produced higher complete r...
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Article
Identification and validation of seven genes, as potential markers, for the differential diagnosis of small B cell lymphomas (small lymphocytic lymphoma, marginal zone B cell lymphoma and mantle cell lymphoma) by cDNA macroarrays analysis
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Article
Multifocal progressive leukoencephalopathy occurring after refractory anemia and multiple infectious disorders consecutive to severe lymphopenia
Progressive multifocal leukoencephalopathy (PML) is related to central nervous system infection with JC virus (JCV). This leukoencephalopathy occurs in immunocompromised patients such as those with acquired i...
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Article
A prospective study of intensive induction therapy with high-dose consolidation in patients with aggressive non-Hodgkin's lymphoma and two or three adverse prognostic factors
Patients with nhl and two or three factors of the international prognostic index (ipi) have a poor prognosis. we performed a prospective trial of intensive induction therapy followed with high-dose consolidati...
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Article
Profiles and prognostic values of LDH isoenzymes in patients with non-Hodgkin’s lymphoma
Serum lactic dehydrogenase (LDH) is an important prognostic factor in patients with non-Hodgkin’s lymphoma (NHL). We have examined the LDH isoenzyme content in serum and CSF of patients with NHL, at diagnosis ...
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Article
Translocations involving the short arm of chromosome 17 in chronic B-lymphoid disorders: frequent occurrence of dicentric rearrangements and possible association with adverse outcome
Unbalanced translocations involving chromosome arm 17p, where the TP53 tumor suppressor gene localizes, are rarely described in chronic lymphocytic leukemia and small lymphocytic lymphoma (CLL/SLL), but recent...
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Chapter
Risk-related treatment strategies for diffuse large B cell lymphoma
Patients with large cell lymphoma have differing prognoses. Even within a single histologic subtype, outcome is influenced by a number of factors (not all of which are recognized), and the optimal treatment di...
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Chapter
Optimal treatment strategies for peripheral T cell lymphoma (unspecified category)
This review combines peripheral “T cell lymphoma, unspecified”, whatever the cell morphology and the specific variants described in the REAL classification [29.1]. If one is going to identify clinical differen...
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Chapter
Clinical aspects and treatment options of B cell CLL/SLL and immunocytoma
One of the merits of the REAL classification is that it emphasizes different entities and particularly small lymphocytic and lymphoplasmacytic lymphomas. As noted in a preceding chapter, small lymphocytic lymp...
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Article
Mantle cell lymphoma: a retrospective study of 121 cases
Mantle cell lymphoma (MCL) patients represent a difficult problem, sometimes to establish the diagnosis but mostly because of their refractoriness to standard lymphoma treatments. Which treatments to apply and...
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Article
Plasma levels of tumour necrosis factor and its soluble receptors correlate with clinical features and outcome of Hodgkin's disease patients
A prospective study was performed to assess the use of plasma measurement of tumour necrosis factor (TNF), lymphotoxin alpha (LT alpha) and their soluble receptors (p55 and p75) for prognostic risk assignment ...