28 Result(s)

Article

Monoclonal antibody therapy in multiple myeloma

The therapeutic landscape of multiple myeloma (MM) has evolved spectacularly over the past decade with the discovery and validation of proteasome inhibitors and immunomodulatory agents as highly active agents,...

C Touzeau, P Moreau, C Dumontet in Leukemia (2017)

Article

Polymorphisms in xenobiotic transporters ABCB1, ABCG2, ABCC2, ABCC1, ABCC3 and multiple myeloma risk: a case–control study in the context of the International Multiple Myeloma rESEarch (IMMEnSE) consortium

A Martino, D Campa, G Buda, J Sainz, R García-Sanz, K Jamroziak, R M Reis… in Leukemia (2012)

Article

Zidovudine (AZT) has a bactericidal effect on enterobacteria and induces genetic modifications in resistant strains

The spread of multiresistant bacteria increases the need for new antibiotics. The observation that some nucleoside analogues have antibacterial activity led us to further investigate the antimicrobial activity...

A. Doléans-Jordheim, E. Bergeron… in European Journal of Clinical Microbiology … (2011)

Article

Genetic polymorphisms associated with outcome in multiple myeloma patients receiving high-dose melphalan

High-dose melphalan (HDM) is an essential component in the treatment of patients with multiple myeloma (MM). Few data are available regarding genetic polymorphisms associated with patient outcome or toxicity i...

C Dumontet, S Landi, T Reiman, T Perry, A Plesa, I Bellini… in Bone Marrow Transplantation (2010)

Article

Development of gene therapy in association with clinically used cytotoxic deoxynucleoside analogues

The clinical use of cytotoxic deoxynucleoside analogues is often limited by resistance mechanisms due to enzymatic deficiency, or high toxicity in nontumor tissues. To improve the use of these drugs, gene ther...

C Hébrard, C Dumontet, L P Jordheim in Cancer Gene Therapy (2009)

Article

Jatrophane diterpenes from Euphorbia spp. as modulators of multidrug resistance in cancer therapy

A phytochemical investigation of the aerial parts of Euphorbia spp., considered one of the most common elements of Mediterranean landascape, led to the isolation of a large number of bioactive plant metabolites, ...

G. Corea, A. Di Pietro, C. Dumontet, E. Fattorusso, V. Lanzotti in Phytochemistry Reviews (2009)

Article

A20/TNFAIP3, a new estrogen-regulated gene that confers tamoxifen resistance in breast cancer cells

The zinc-finger protein A20/TNFAIP3, an inhibitor of nuclear factor-κB (NF-κB) activation, has been shown to protect MCF-7 breast carcinoma cells from TNFα-induced apoptosis. As estrogen receptor (ER) status is a...

J A Vendrell, S Ghayad, S Ben-Larbi, C Dumontet, N Mechti, P A Cohen in Oncogene (2007)

Article

Rituximab in CD20 positive multiple myeloma

P Moreau, L Voillat, L Benboukher, C Mathiot, C Dumontet, N Robillard… in Leukemia (2007)

Article

Autoimmune thrombocytopenic purpura after autologous stem cell transplantation

The pathogenesis of thrombocytopenia occurring after autologous stem cell transplantation (ASCT) remains unclear. Six cases of classical peripheral thrombocytopenia that developed after ASCT for non-Hodgkin's ...

O Hequet, G Salles, N Ketterer, D Espinouse, C Dumontet… in Bone Marrow Transplantation (2003)

Article

Amifostine reduces mucosal damage after high-dose melphalan conditioning and autologous peripheral blood progenitor cell transplantation for patients with multiple myeloma

High-dose melphalan (HDM) has been adopted as standard therapy in the treatment of multiple myeloma. This treatment is associated with non-selective cytotoxicity, causing oral mucositis as the major non-hemato...

C Thieblemont, C Dumontet, H Saad, N Roch, F Bouafia… in Bone Marrow Transplantation (2002)

Article

Identification and validation of seven genes, as potential markers, for the differential diagnosis of small B cell lymphomas (small lymphocytic lymphoma, marginal zone B cell lymphoma and mantle cell lymphoma) by cDNA macroarrays analysis

C Thieblemont, K Chettab, P Felman, E Callet-Bauchu, A Traverse-Glehen… in Leukemia (2002)

Article

Multifocal progressive leukoencephalopathy occurring after refractory anemia and multiple infectious disorders consecutive to severe lymphopenia

Progressive multifocal leukoencephalopathy (PML) is related to central nervous system infection with JC virus (JCV). This leukoencephalopathy occurs in immunocompromised patients such as those with acquired i...

O. Hequet, G. Salles, D. Espinousse, C. Dumontet, F. Bouafia… in Annals of Hematology (2002)

Article

Epileptic seizures after autologous peripheral blood progenitor infusion in a patient treated with high-dose chemotherapy for myeloma

Bone Marrow Transplantation (2002) 29, 544. doi:10.1038/sj.bmt.1703383

O Hequet, C Dumontet, A El Jaafari-Corbin, G Salles… in Bone Marrow Transplantation (2002)

Article

Modulation by flavonoids of cell multidrug resistance mediated by P-glycoprotein and related ABC transporters

Cancer cell resistance to chemotherapy is often mediated by overexpression of P-glycoprotein, a plasma membrane ABC (ATP-binding cassette) transporter which extrudes cytotoxic drugs at the expense of ATP hydr...

A. Di Pietro, G. Conseil, J.M. Pérez-Victoria… in Cellular and Molecular Life Sciences CMLS (2002)

Article

Nucleoside analogues: mechanisms of drug resistance and reversal strategies

Nucleoside analogues (NA) are essential components of AML induction therapy (cytosine arabinoside), effective treatments of lymphoproliferative disorders (fludarabine, cladribine) and are also used in the trea...

CM Galmarini, JR Mackey, C Dumontet in Leukemia (2001)