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Biomedicine
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Article
Open AccessNeutralizing RGMa with Elezanumab Promotes Cerebroprotection and Recovery in Rabbit Middle Cerebral Artery Occlusion
Repulsive guidance molecule A (RGMa) is an inhibitor of neuronal growth and survival which is upregulated in the damaged central nervous system following acute spinal cord injury (SCI), traumatic brain injury,...
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3D Characterization of the Aortic Valve and Aortic Arch in Bicuspid Aortic Valve Patients
Patients with bicuspid aortic valve (BAV) commonly have associated aortic stenosis and aortopathy. The geometry of the aortic arch and BAV is not well defined quantitatively, which makes clinical classificatio...
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Open AccessInstitution-Wide Retreats Foster Organizational Learning and Action at a Comprehensive Cancer Center
Providing safe and informed healthcare for sexual and gender minority (SGM) individuals with cancer is stymied by the lack of sexual orientation and gender identity (SOGI) data reliably available in health rec...
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The Lure of the Podium: The Seductive Appeal of Predatory Conference Speaker Invitations
This letter highlights an escalating concern regarding predatory conference speaker invitations that are currently plaguing academia. Such invitations are frequently issued to individuals outside their areas o...
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Synthesis and in vitro assessment of the reactivation profile of clinically available oximes on the acetylcholinesterase model inhibited by A-230 nerve agent surrogate
The risk of the use of toxic chemicals for unlawful acts has been a matter of concern for different governments and multilateral agencies. The Organisation for the Prohibition of Chemical Weapons (OPCW), which...
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Open AccessSusceptibility gene mutations in germline and tumors of patients with HER2-negative advanced breast cancer
Germline mutations in BRCA1 and BRCA2 (gBRCA1/2) are required for a PARP inhibitor therapy in patients with HER2-negative (HER2−) advanced breast cancer (aBC). However, little is known about the prognostic impact...
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The AKT inhibitor AZD5363 elicits synthetic lethality in ARID1A-deficient gastric cancer cells via induction of pyroptosis
Gastric cancer (GC) is a deadly disease with poor overall survival and limited therapeutic options. Genetic alterations such as mutations and/or deletions in chromatin remodeling gene AT-rich interactive domai...
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Correction: Development of an optimized AAV2/5 gene therapy vector for Leber congenital amaurosis owing to defects in RPE65
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Open AccessDisruption of neural periodicity predicts clinical response after deep brain stimulation for obsessive-compulsive disorder
Recent advances in surgical neuromodulation have enabled chronic and continuous intracranial monitoring during everyday life. We used this opportunity to identify neural predictors of clinical state in 12 indi...
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Open AccessPriming antibody responses to the fusion peptide in rhesus macaques
Immunodominance of antibodies targeting non-neutralizing epitopes and the high level of somatic hypermutation within germinal centers (GCs) required for most HIV broadly neutralizing antibodies (bnAbs) are maj...
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Open AccessLipidome changes due to improved dietary fat quality inform cardiometabolic risk reduction and precision nutrition
Current cardiometabolic disease prevention guidelines recommend increasing dietary unsaturated fat intake while reducing saturated fats. Here we use lipidomics data from a randomized controlled dietary interve...
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Open AccessAn end-to-end workflow to study newly synthesized mRNA following rapid protein depletion in Saccharomyces cerevisiae
Gene transcription by RNA polymerase II is a fundamental process in eukaryotic cells. The precise regulation of transcription is necessary for cellular growth and development and requires the coordinated activ...
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Open AccessHuman Babesia odocoilei and Bartonella spp. co-infections in the Americas
In recent years, Babesia and Bartonella species co-infections in patients with chronic, nonspecific illnesses have continued to challenge and change the collective medical understanding of “individual pathogen” v...
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Open AccessThe role of microglia in early neurodevelopment and the effects of maternal immune activation
Activation of the maternal immune system during gestation has been associated with an increased risk for neurodevelopmental disorders in the offspring, particularly schizophrenia and autism spectrum disorder. ...
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Evaluation of the influence of the duration of the pause between the phases of depolarizing biphasic half-sinusoidal and truncated exponential defibrillation pulses on their energy efficiency
Data obtained from simulation the responses of cardiomyocytes in a state of simulated fibrillation to depolarizing biphasic half-sinusoidal and truncated exponential defibrillation pulses with pauses of differ...
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A medical scanner for focusing and positioning laser radiation onto a patient’s skin
A medical scanner has been developed for the treatment of pigmented, vascular, and unpigmented skin defects using a copper vapor laser at two generation wavelengths, 511 and 578 nm. Different skin diseases can...
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Open AccessEpidemiology of biliary tract-associated bloodstream infections and adequacy of empiric therapy: an Australian population-based study
Although the biliary tract is a common source of invasive infections, the epidemiology of cholangitis- and cholecystitis-associated bloodstream infection (BSI) is not well defined. The objective of this study ...
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Open AccessOn the Importance of Including Cohesive Zone Models in Modelling Mixed-Mode Aneurysm Rupture
The precise mechanism of rupture in abdominal aortic aneurysms (AAAs) has not yet been uncovered. The phenomenological failure criterion of the coefficient of proportionality between von Mises stress and tissu...
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Open AccessCreation and validation of the first infinium DNA methylation array for the human imprintome
Differentially methylated imprint control regions (ICRs) regulate the monoallelic expression of imprinted genes. Their epigenetic dysregulation by environmental exposures throughout life results in the formati...
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CREB-Binding Protein Regulates Cocaine- and Amphetamine-Regulated Transcript Peptide Expression in the Lateral Hypothalamus: Implication in Reward and Reinforcement
Neuropeptide cocaine- and amphetamine-regulated transcript peptide (CARTp) is known to play an important role in reward processing. The rats conditioned to intra-cranial self-stimulation (ICSS) showed massive ...
