10 Result(s)
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Benjamin R. Schrank
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Article
Open AccessInstitution-Wide Retreats Foster Organizational Learning and Action at a Comprehensive Cancer Center
Providing safe and informed healthcare for sexual and gender minority (SGM) individuals with cancer is stymied by the lack of sexual orientation and gender identity (SOGI) data reliably available in health rec...
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Synthetic cationic helical polypeptides for the stimulation of antitumour innate immune pathways in antigen-presenting cells
Intracellular DNA sensors regulate innate immunity and can provide a bridge to adaptive immunogenicity. However, the activation of the sensors in antigen-presenting cells (APCs) by natural agonists such as dou...
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Article
Age-associated disparity in phagocytic clearance affects the efficacy of cancer nanotherapeutics
Nanomedicines have been approved to treat multiple human diseases. However, clinical adoption of nanoformulated agents is often hindered by concerns about hepatic uptake and clearance, a process that is not fu...
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Open AccessAdaptive design of mRNA-loaded extracellular vesicles for targeted immunotherapy of cancer
The recent success of mRNA therapeutics against pathogenic infections has increased interest in their use for other human diseases including cancer. However, the precise delivery of the genetic cargo to cells ...
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Open AccessAuthor Correction: Multiscale reorganization of the genome following DNA damage facilitates chromosome translocations via nuclear actin polymerization
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Intradermally delivered mRNA-encapsulating extracellular vesicles for collagen-replacement therapy
The success of messenger RNA therapeutics largely depends on the availability of delivery systems that enable the safe, effective and stable translation of genetic material into functional proteins. Here we sh...
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Open AccessMultiscale reorganization of the genome following DNA damage facilitates chromosome translocations via nuclear actin polymerization
Nuclear actin-based movements have been shown to orchestrate clustering of DNA double-strand breaks (DSBs) into homology-directed repair domains. Here we describe multiscale three-dimensional genome reorganiza...
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Immunological conversion of solid tumours using a bispecific nanobioconjugate for cancer immunotherapy
Solid tumours display a limited response to immunotherapies. By contrast, haematological malignancies exhibit significantly higher response rates to immunotherapies as compared with solid tumours. Among severa...
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Nuclear ARP2/3 drives DNA break clustering for homology-directed repair
DNA double-strand breaks repaired by non-homologous end joining display limited DNA end-processing and chromosomal mobility. By contrast, double-strand breaks undergoing homology-directed repair exhibit extens...
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Article
Aβ alters the connectivity of olfactory neurons in the absence of amyloid plaques in vivo
The amyloid beta peptide aggregates into amyloid plaques at presymptomatic stages of Alzheimer's disease, but the temporal relationship between plaque formation and neuronal dysfunction is poorly understood. H...
