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  1. No Access

    Article

    Alterations in the p16INK4a and p53 tumor suppressor genes of hTERT-immortalized human fibroblasts

    Exogenous expression of the catalytic subunit of telomerase, hTERT, in a normal human foreskin fibroblast cell strain resulted in telomerase activity and an extended proliferative lifespan prior to a period of...

    Jane R Noble, Ze-Huai Zhong, Axel A Neumann, John R Melki, Susan J Clark… in Oncogene (2004)

  2. No Access

    Article

    Alternative lengthening of telomeres in mammalian cells

    Some immortalized mammalian cell lines and tumors maintain or increase the overall length of their telomeres in the absence of telomerase activity by one or more mechanisms referred to as alternative lengtheni...

    Jeremy D Henson, Axel A Neumann, Thomas R Yeager, Roger R Reddel in Oncogene (2002)

  3. No Access

    Article

    Comparison of human mammary epithelial cells immortalized by simian virus 40 T-Antigen or by the telomerase catalytic subunit

    We directly compared two methods of immortalizing human mammary epithelial cells (HMECs). Cells were transfected with an expression plasmid either for hTERT, the catalytic subunit of telomerase, or for the sim...

    Christian D Toouli, Lily I Huschtscha, Axel A Neumann, Jane R Noble… in Oncogene (2002)

  4. No Access

    Article

    Telomere maintenance by recombination in human cells

    Telomeres of eukaryotic chromosomes contain many tandem repeats of a G-rich sequence (for example, TTAGGG in vertebrates1). In most normal human cells, telomeres shorten with each cell division, and it is propose...

    Melissa A. Dunham, Axel A. Neumann, Clare L. Fasching, Roger R. Reddel in Nature Genetics (2000)