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  1. No Access

    Article

    Telomere maintenance by recombination in human cells

    Telomeres of eukaryotic chromosomes contain many tandem repeats of a G-rich sequence (for example, TTAGGG in vertebrates1). In most normal human cells, telomeres shorten with each cell division, and it is propose...

    Melissa A. Dunham, Axel A. Neumann, Clare L. Fasching, Roger R. Reddel in Nature Genetics (2000)

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    Article

    Evidence for an alternative mechanism for maintaining telomere length in human tumors and tumor-derived cell lines

    The gradual loss of DNA from the ends of telomeres has been implicated in the control of cellular proliferative potential1–3. Telomerase is an enzyme that restores telomeric DNA sequences4, and expression of its ...

    Tracy M. Bryan, Anna Englezou, Luciano Dalla-Pozza, Melissa A. Dunham… in Nature Medicine (1997)