6 Result(s)
within
Asia Fernández-Carvajal
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Article
Open AccessTRPM8 contributes to sex dimorphism by promoting recovery of normal sensitivity in a mouse model of chronic migraine
TRPA1 and TRPM8 are transient receptor potential channels expressed in trigeminal neurons that are related to pathophysiology in migraine models. Here we use a mouse model of nitroglycerine-induced chronic mig...
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Article
Open AccessA capsaicinoid-based soft drug, AG1529, for attenuating TRPV1-mediated histaminergic and inflammatory sensory neuron excitability
TRPV1, a member of the transient receptor potential (TRP) family, is a nonselective calcium permeable ion channel gated by physical and chemical stimuli. In the skin, TRPV1 plays an important role in neurogeni...
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Article
Open AccessHighly functionalized β-lactams and 2-ketopiperazines as TRPM8 antagonists with antiallodynic activity
The cool sensor transient receptor potential melastatin channel 8 (TRPM8) is highly expressed in trigeminal and dorsal root ganglia, playing a key role in cold hypersensitivity associated to different peripher...
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Protocol
Fluorescence-Based Functional Assays for Ca2+-Permeable ThermoTRP Channels
Transient receptor potential (TRP) ion channels are involved in a variety of fundamental physiological processes, and their malfunction produces numerous human diseases. Therefore, these proteins represent a c...
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Article
Open AccessSynthesis, high-throughput screening and pharmacological characterization of β–lactam derivatives as TRPM8 antagonists
The mammalian transient receptor potential melastatin channel 8 (TRPM8), highly expressed in trigeminal and dorsal root ganglia, mediates the cooling sensation and plays an important role in the cold hypersens...
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Chapter
Pharmacology of TRP Channels
TRP channels are a family of ion channels involved in a plethora of physiological sensory processes. Since their discovery they have attracted the attention of academic and non-academic laboratories with the a...
