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  1. Article

    Open Access

    Tumor-produced and aging-associated oncometabolite methylmalonic acid promotes cancer-associated fibroblast activation to drive metastatic progression

    The systemic metabolic shifts that occur during aging and the local metabolic alterations of a tumor, its stroma and their communication cooperate to establish a unique tumor microenvironment (TME) fostering c...

    Zhongchi Li, Vivien Low, Valbona Luga, Janet Sun, Ethan Earlie… in Nature Communications (2022)

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  2. Article

    Open Access

    A lateral signalling pathway coordinates shape volatility during cell migration

    Cell migration is fundamental for both physiological and pathological processes. Migrating cells usually display high dynamics in morphology, which is orchestrated by an integrative array of signalling pathway...

    Liang Zhang, Valbona Luga, Sarah K. Armitage, Martin Musiol… in Nature Communications (2016)

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  3. No Access

    Article

    Loss of the Timp gene family is sufficient for the acquisition of the CAF-like cell state

    Cancer-associated fibroblasts (CAFs) drive tumour progression, but the emergence of this cell state is poorly understood. A broad spectrum of metalloproteinases, controlled by the Timp gene family, influence the ...

    Masayuki Shimoda, Simona Principe, Hartland W. Jackson, Valbona Luga… in Nature Cell Biology (2014)