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Article
Open AccessCancer prevention and screening: the next step in the era of precision medicine
A primary mode of cancer prevention and early detection in the United States is the widespread practice of screening. Although many strategies for early detection and prevention are available, adverse outcomes...
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Article
Open AccessImmunoprevention approaches for cancer prevention
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Article
Future directions in cancer prevention
In the past three decades, the approach to cancer prevention has moved from population and epidemiological studies to molecular targeting and immunological app...
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Chapter and Conference Paper
Can Animal Models Help Us Select Specific Compounds for Cancer Prevention Trials?
Animal models provide unparalleled mechanistic insights into cancer development and potential opportunity for cancer prevention. Nevertheless, species differ markedly with regard to dietary exposures, cancer d...
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Article
Testing guidelines for hereditary non-polyposis colorectal cancer
Hereditary non-polyposis colorectal cancer is almost always associated with microsatellite instability, so what is the best way to identify the disorder at an early-stage, and what should the next step be in p...
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Article
Colorectal carcinoma in black and white race
Worldwide, colorectal carcinoma (CRC) varies by race-ethnicity. The highest incidence occurs in whites of European descent. Rates in blacks of South Africa are much lower, but rise with migration to westernize...
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Article
Hydrogeological and hydrochemical framework of regional aquifer system in Kali-Ganga sub-basin, India
The central Ganga Basin is one of the major groundwater reservoirs in India. The Kali-Ganga sub-basin is a micro watershed of the central Ganga Basin, containing a number of productive aquifers. A detailed hy...
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Chapter
DNA-replication fidelity, mismatch repair and genome instability in cancer cells
It has been suggested that an early event in the multistep progression of a normal cell to a tumor cell could be a defect that leads to an elevated mutation rate, thus providing a pool of mutants upon which se...
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Article
Mutation of MSH3 in endometrial cancer and evidence for its functional role in heteroduplex repair
Many human tumours have length alterations in repetitive sequence elements1. Although this microsatellite instability has been attributed to mutations in four DNA mismatch repair genes in hereditary nonpolyposis ...
