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  1. Article

    Open Access

    SnapHiC: a computational pipeline to identify chromatin loops from single-cell Hi-C data

    Single-cell Hi-C (scHi-C) analysis has been increasingly used to map chromatin architecture in diverse tissue contexts, but computational tools to define chromatin loops at high resolution from scHi-C data are...

    Miao Yu, Armen Abnousi, Yanxiao Zhang, Guoqiang Li, Lindsay Lee in Nature Methods (2021)

  2. No Access

    Article

    An ultra high-throughput method for single-cell joint analysis of open chromatin and transcriptome

    Simultaneous profiling of transcriptome and chromatin accessibility within single cells is a powerful approach to dissect gene regulatory programs in complex tissues. However, current tools are limited by mode...

    Chenxu Zhu, Miao Yu, Hui Huang, Ivan Juric in Nature Structural & Molecular Biology (2019)