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Article
Open AccessMetabolic impairment of non-small cell lung cancers by mitochondrial HSPD1 targeting
The identification of novel targets is of paramount importance to develop more effective drugs and improve the treatment of non-small cell lung cancer (NSCLC), the leading cause of cancer-related deaths worldw...
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Article
Open AccessThe role of miR-200b/c in balancing EMT and proliferation revealed by an activity reporter
Since their discovery, microRNAs (miRNAs) have been widely studied in almost every aspect of biology and medicine, leading to the identification of important gene regulation circuits and cellular mechanisms. H...
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Article
Open AccessThymidylate synthase drives the phenotypes of epithelial-to-mesenchymal transition in non-small cell lung cancer
Epithelial-to-mesenchymal transition (EMT) enhances motility, stemness, chemoresistance and metastasis. Little is known about how various pathways coordinate to elicit EMT’s different functional aspects in non...
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Article
Open AccessThymidylate synthase maintains the de-differentiated state of triple negative breast cancers
Cancer cells frequently boost nucleotide metabolism (NM) to support their increased proliferation, but the consequences of elevated NM on tumor de-differentiation are mostly unexplored. Here, we identified a r...
