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  1. Article

    Open Access

    Modeling the early stages of Alzheimer’s disease by administering intracerebroventricular injections of human native Aβ oligomers to rats

    Alzheimer’s disease (AD) is a progressive and irreversible neurodegenerative disease characterized by the accumulation of aggregated amyloid beta (Aβ) and hyperphosphorylated tau along with a slow decline in c...

    Eva Baerends, Katia Soud, Jonas Folke… in Acta Neuropathologica Communications (2022)

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  2. No Access

    Article

    UbiSite approach for comprehensive map** of lysine and N-terminal ubiquitination sites

    Ubiquitination is a post-translational modification (PTM) that is essential for balancing numerous physiological processes. To enable delineation of protein ubiquitination at a site-specific level, we generate...

    Vyacheslav Akimov, Inigo Barrio-Hernandez… in Nature Structural & Molecular Biology (2018)

  3. Article

    Open Access

    Molecular basis of Tousled-Like Kinase 2 activation

    Tousled-like kinases (TLKs) are required for genome stability and normal development in numerous organisms and have been implicated in breast cancer and intellectual disability. In humans, the similar TLK1 and...

    Gulnahar B. Mortuza, Dario Hermida, Anna-Kathrine Pedersen… in Nature Communications (2018)

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  4. No Access

    Article

    Multilayered proteomics reveals molecular switches dictating ligand-dependent EGFR trafficking

    Analysis of changes in the EGFR interactome, ubiquitinome, phosphoproteome and proteome in response to EGF or TGF-α identifies RAB7 phosphorylation and RCP recruitment to EGFR as ligand-specific switches contr...

    Chiara Francavilla, Moreno Papetti… in Nature Structural & Molecular Biology (2016)