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Characterizing prostate cancer risk through multi-ancestry genome-wide discovery of 187 novel risk variants
The transferability and clinical value of genetic risk scores (GRSs) across populations remain limited due to an imbalance in genetic studies across ancestrally diverse populations. Here we conducted a multi-a...
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Article
Overall and central obesity and prostate cancer risk in African men
African men are disproportionately affected by prostate cancer (PCa). Given the increasing prevalence of obesity in Africa, and its association with aggressive PCa in other populations, we examined the relatio...
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Publisher Correction: Trans-ancestry genome-wide association meta-analysis of prostate cancer identifies new susceptibility loci and informs genetic risk prediction
A Correction to this paper has been published: https://doi.org/10.1038/s41588-021-00786-2.
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Article
Trans-ancestry genome-wide association meta-analysis of prostate cancer identifies new susceptibility loci and informs genetic risk prediction
Prostate cancer is a highly heritable disease with large disparities in incidence rates across ancestry populations. We conducted a multiancestry meta-analysis of prostate cancer genome-wide association studie...
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Article
Open AccessMetabolomic profiles in breast cancer:a pilot case-control study in the breast cancer family registry
Metabolomics is emerging as an important tool for detecting differences between diseased and non-diseased individuals. However, prospective studies are limited.
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Article
Serum androgens and prostate cancer risk: results from the placebo arm of the Prostate Cancer Prevention Trial
Compelling and long-standing data suggest that androgens play an important role in the development of both normal prostate epithelium and prostate cancer. Although testosterone administration can induce prosta...
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Article
Prospective study of human herpesvirus type 8 serostatus and prostate cancer risk in the placebo arm of the Prostate Cancer Prevention Trial
Human herpesvirus type 8 (HHV-8), a gamma herpesvirus associated with Kaposi’s sarcoma, has been proposed as a candidate risk factor for prostate cancer (PCa) because of its detection in benign and malignant p...
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Article
A meta-analysis of 87,040 individuals identifies 23 new susceptibility loci for prostate cancer
Rosalind Eeles, Christopher Haiman and colleagues report genome-wide association and meta-analyses of prostate cancer in populations of European, African, Japanese and Latino ancestry. They identify 23 new sus...
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Erratum to: A genome-wide association study of prostate cancer in West African men
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A genome-wide association study of prostate cancer in West African men
Age-adjusted mortality rates for prostate cancer are higher for African-American men compared with those of European ancestry. Recent data suggest that West African men also have elevated risk for prostate can...
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Article
Open AccessInflammatory gene variants and the risk of biliary tract cancers and stones: a population-based study in China
Genetic variants in inflammation-related genes have been associated with biliary stones and biliary tract cancers in previous studies.
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Article
Prospective study of cytomegalovirus serostatus and prostate cancer risk in the Prostate Cancer Prevention Trial
To investigate serologic evidence of infection by cytomegalovirus (CMV), a herpesvirus with known oncogenic potential that has been detected in malignant prostate tissue, in relation to prostate cancer (PCa) r...
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Article
Detectable clonal mosaicism and its relationship to aging and cancer
Luis Pérez-Jurado, Stephen Chanock and colleagues detect clonal chromosomal abnormalities in peripheral blood or buccal samples from individuals in the general population. They show that the frequency of such ...
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Article
Physical activity, diabetes, and thyroid cancer risk: a pooled analysis of five prospective studies
Although many studies have linked obesity with increased risk of thyroid cancer, few have investigated the role of obesity-related lifestyle characteristics and medical conditions in the etiology of this disea...
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Article
Improved imputation of common and uncommon SNPs with a new reference set
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Medical history and the risk of biliary tract cancers in Shanghai, China: implications for a role of inflammation
Several lines of evidence suggest that inflammation may play a role in the etiology of biliary tract cancers. To examine further the role of inflammation, we evaluated the associations between self-reported in...
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Article
Open AccessSerum estrogen levels and prostate cancer risk in the prostate cancer prevention trial: a nested case–control study
Finasteride reduces prostate cancer risk by blocking the conversion of testosterone to dihydrotestosterone. However, whether finasteride affects estrogens levels or change in estrogens affects prostate cancer ...
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Dietary carbohydrate, glycemic index, glycemic load, and risk of prostate cancer in the Prostate, Lung, Colorectal, and Ovarian Cancer Screening Trial (PLCO) cohort
To evaluate the associations between dietary carbohydrate, glycemic index (GI), glycemic load (GL), and incident prostate cancer in the Prostate, Lung, Colorectal, and Ovarian Cancer Screening Trial (PLCO) coh...
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Article
Genome-wide association study of prostate cancer in men of African ancestry identifies a susceptibility locus at 17q21
Christopher Haiman and colleagues report a genome-wide association study for prostate cancer in African-American males drawn from 11 epidemiological studies of prostate cancer, with replication including indiv...
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Open AccessChronic typhoid infection and the risk of biliary tract cancer and stones in Shanghai, China
Previous studies have shown a positive association between chronic typhoid carriage and biliary cancers. We compared serum Salmonella enterica serovar Typhi antibody titers between biliary tract cancer cases, bil...