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Article
Adenovirus early region 1A protein binds to mammalian SUG1-a regulatory component of the proteasome
Adenovirus early region 1A (Ad E1A) is a multifunctional protein which is essential for adenovirus-mediated transformation and oncogenesis. Whilst E1A is generally considered to exert its influence on recipien...
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Article
Consequences of disruption of the interaction between p53 and the larger adenovirus early region 1B protein in adenovirus E1 transformed human cells
The adenovirus early region 1B (Ad E1B) genes have no transforming capability of their own but markedly increase the transformation frequency of Ad E1A following co-transfection into mammalian cells. The large...
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Article
Adenovirus E1A: remodelling the host cell, a life or death experience
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Article
The APC/C and CBP/p300 cooperate to regulate transcription and cell-cycle progression
The anaphase-promoting complex/cyclosome (APC/C) is a multicomponent E3 ubiquitin ligase that, by targeting protein substrates for 26S proteasome-mediated degradation through ubiquitination, coordinates the te...
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Reference Work Entry In depth
CBP/p300 Coactivators
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Article
Tumour angiogenesis is reduced in the Tc1 mouse model of Down’s syndrome
Down's syndrome is caused by the presence of an extra copy of chromosome 21 (a state known as trisomy), and it is known that the growth of certain tumours is reduced in this genetic disorder. A study of a mous...
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Article
Erratum: Tumour angiogenesis is reduced in the Tc1 mouse model of Down’s syndrome
Nature 465, 813–817 (2010) In this Letter, the address for author Ralf H. Adams was listed incorrectly. The correct address is: Department of Tissue Morphogenesis, Max-Planck-Institute for Molecular Biomedicin...
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Living Reference Work Entry In depth
CBP/p300 Coactivators
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Reference Work Entry In depth
CBP/p300 Coactivators
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Article
Open AccessMeeting abstracts from the 64th British Thyroid Association Annual Meeting
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Article
Open AccessDeep splicing plasticity of the human adenovirus type 5 transcriptome drives virus evolution
Viral genomes have high gene densities and complex transcription strategies rendering transcriptome analysis through short-read RNA-seq approaches problematic. Adenovirus transcription and splicing is especial...