Definition
CBP is an acronym for cAMP-regulated-enhancer (CRE)-binding protein (CREB)-binding protein. p300 is a protein that is highly homologous to CBP and has been named according to its approximate molecular weight. Coactivators are a group of cellular proteins that enhance transcription factor-dependent transcriptional activation.
Characteristics
CBP was initially identified as an auxiliary cofactor required for the CREB-mediated activation of cAMP-stimulated gene transcription. CBP binds specifically, at CREs, to an activated CREB species which has been suitably modified through phosphorylation by the cAMP-responsive protein kinase, PKA. p300 was subsequently characterized, independently, upon the basis of its interaction with the protein product of the adenoviral transforming E1Agene and, like CBP, can function as a coactivator in CREB-mediated transcriptional activation. CBP, akin to p300, also binds to E1A. CBP and p300 are highly related at the amino acid sequence level,...
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References
Goodman RH, Smolik S (2000) CBP/p300 in cell growth, transformation and development. Genes Dev 14:1553–1577
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Turnell AS, Mymryk JS (2006) Roles for the coactivators CBP and p300 and the APC/C E3 ubiquitin ligase in E1A-dependent cell transformation. Br J Cancer 95:555–560
See Also
(2012) Acetyltransferase. In: Schwab M (ed) Encyclopedia of cancer, 3rd edn. Springer Berlin Heidelberg, p 17. doi: 10.1007/978-3-642-16483-5_27
(2012) Cell cycle. In: Schwab M (ed) Encyclopedia of cancer, 3rd edn. Springer Berlin Heidelberg, p 737. doi: 10.1007/978-3-642-16483-5_994
(2012) Chromatin. In: Schwab M (ed) Encyclopedia of cancer, 3rd edn. Springer Berlin Heidelberg, p 825. doi: 10.1007/978-3-642-16483-5_1125
(2012) Differentiation. In: Schwab M (ed) Encyclopedia of cancer, 3rd edn. Springer Berlin Heidelberg, p 1113. doi: 10.1007/978-3-642-16483-5_1616
(2012) E3 ubiquitin ligase. In: Schwab M (ed) Encyclopedia of cancer, 3rd edn. Springer Berlin Heidelberg, p 1184. doi: 10.1007/978-3-642-16483-5_1771
(2012) E4 ubiquitin ligase. In: Schwab M (ed) Encyclopedia of cancer, 3rd edn. Springer Berlin Heidelberg, p 1184. doi: 10.1007/978-3-642-16483-5_1772
(2012) Loss of heterozygosity. In: Schwab M (ed) Encyclopedia of cancer, 3rd edn. Springer Berlin Heidelberg, pp 2075–2076. doi: 10.1007/978-3-642-16483-5_3415
(2012) P53. In: Schwab M (ed) Encyclopedia of cancer, 3rd edn. Springer Berlin Heidelberg, p 2747. doi: 10.1007/978-3-642-16483-5_4331
(2012) Transcription. In: Schwab M (ed) Encyclopedia of cancer, 3rd edn. Springer Berlin Heidelberg, p 3752. doi: 10.1007/978-3-642-16483-5_5899
(2012) Transformation. In: Schwab M (ed) Encyclopedia of Cancer, 3rd edn. Springer Berlin Heidelberg, pp 3757–3758. doi: 10.1007/978-3-642-16483-5_5913
(2012) Tumor suppressor. In: Schwab M (ed) Encyclopedia of cancer, 3rd edn. Springer Berlin Heidelberg, p 3803. doi: 10.1007/978-3-642-16483-5_6056
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Turnell, A.S. (2015). CBP/p300 Coactivators. In: Schwab, M. (eds) Encyclopedia of Cancer. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-27841-9_899-2
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DOI: https://doi.org/10.1007/978-3-642-27841-9_899-2
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