5 Result(s)

Article

A molnupiravir-associated mutational signature in global SARS-CoV-2 genomes

Molnupiravir, an antiviral medication widely used against severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), acts by inducing mutations in the virus genome during replication. Most random mutations ...

Theo Sanderson, Ryan Hisner, I’ah Donovan-Banfield, Hassan Hartman… in Nature (2023)

Article

The P323L substitution in the SARS-CoV-2 polymerase (NSP12) confers a selective advantage during infection

The mutational landscape of SARS-CoV-2 varies at the dominant viral genome sequence and minor genomic variant population. During the COVID-19 pandemic, an early substitution in the genome was the D614G change ...

Hannah Goldswain, **aofeng Dong, Rebekah Penrice-Randal… in Genome Biology (2023)

Article

Tracking outbreak dynamics using within-host variation

I’ah Donovan-Banfield, Edward Cunningham-Oakes in Nature Microbiology (2022)

Article

Characterisation of SARS-CoV-2 genomic variation in response to molnupiravir treatment in the AGILE Phase IIa clinical trial

Molnupiravir is an antiviral, currently approved by the UK Medicines and Healthcare products Regulatory Agency (MHRA) for treating at-risk COVID-19 patients, that induces lethal error catastrophe in SARS-CoV-2...

I’ah Donovan-Banfield, Rebekah Penrice-Randal, Hannah Goldswain… in Nature Communications (2022)

Article

Deep splicing plasticity of the human adenovirus type 5 transcriptome drives virus evolution

Viral genomes have high gene densities and complex transcription strategies rendering transcriptome analysis through short-read RNA-seq approaches problematic. Adenovirus transcription and splicing is especial...

I’ah Donovan-Banfield, Andrew S. Turnell, Julian A. Hiscox… in Communications Biology (2020)