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Article
Open AccessAre there foetal extracellular vesicles in maternal blood? Prospects for diagnostic biomarker discovery
Prenatal diagnosis of congenital disease improves clinical outcomes; however, as many as 50% of congenital heart disease cases are missed by current ultrasound screening methods. This indicates a need for impr...
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Article
19F labelled glycosaminoglycan probes for solution NMR and non-linear (CARS) microscopy
Studying polysaccharide-protein interactions under physiological conditions by conventional techniques is challenging. Ideally, macromolecules could be followed by both in vitro spectroscopy experiments as well a...
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Article
Generating heparan sulfate saccharide libraries for glycomics applications
Natural and semi-synthetic heparan sulfate (HS) saccharide libraries are a valuable resource for investigating HS structure–function relationships, enabling high-throughput glycomics studies. Owing to the diff...
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Protocol
Saccharide Microarrays for High-Throughput Interrogation of Glycan-Protein Binding Interactions
This chapter describes two methods for fabricating microarrays of saccharides for display and interrogation with binding proteins, using fluorescence detection. The first approach is based on the rapid immobil...
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Chapter
Architectures for Optical Neural Networks
Artificial neural networks are parallel processing systems which have applications in speech and pattern recognition (Rumelhart and McCelland, 1986; Prager et al., 1986; Lippmann, 1987; Szu, 1986; Geman and Geman...
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Chapter
The Photorefractive Effect
It is remarkable that photorefractive crystals, such as barium titanate, display such enormous optical nonlinearities with the minimum of optical intensity levels, typically no more than that output from a hel...
