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  1. No Access

    Article

    Anti-Aβ antibody target engagement: a response to Siemers et al.

    Andrew D. Watt, Gabriela A. N. Crespi, Russell A. Down… in Acta Neuropathologica (2014)

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    Article

    Do current therapeutic anti-Aβ antibodies for Alzheimer’s disease engage the target?

    Reducing amyloid-β peptide (Aβ) burden at the pre-symptomatic stages of Alzheimer’s disease (AD) is currently the advocated clinical strategy for treating this disease. The most developed method for targeting ...

    Andrew D. Watt, Gabriela A. N. Crespi, Russell A. Down… in Acta Neuropathologica (2014)

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    Article

    Oligomers, fact or artefact? SDS-PAGE induces dimerization of β-amyloid in human brain samples

    The formation of low-order oligomers of β-amyloid (Aβ) within the brain is widely believed to be a central component of Alzheimer’s disease (AD) pathogenesis. However, despite advances in high-throughput and h...

    Andrew D. Watt, Keyla A. Perez, Alan Rembach, Nicki A. Sherrat… in Acta Neuropathologica (2013)

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    Protocol

    Elucidating the Role of Metals in Alzheimer’s Disease Through the Use of Surface-Enhanced Laser Desorption/Ionisation Time-of-Flight Mass Spectrometry

    Alzheimer’s disease (AD) is a highly heterogeneous and progressive dementia which is characterised by a progressive decline in cognitive functioning, selective neuronal atrophy, and loss of cortical volume in ...

    Andrew D. Watt, Keyla A. Perez, Lin Wai Hung in Protein Folding, Misfolding, and Disease (2011)