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Article
Open AccessRubidium and potassium levels are altered in Alzheimer’s disease brain and blood but not in cerebrospinal fluid
Loss of intracellular compartmentalization of potassium is a biochemical feature of Alzheimer’s disease indicating a loss of membrane integrity and mitochondrial dysfunction. We examined potassium and rubidium...
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Article
Innate phagocytosis by peripheral blood monocytes is altered in Alzheimer’s disease
Sporadic Alzheimer’s disease (AD) is characterised by the deposition and accumulation of specific protein aggregates. Failure of clearance could underlie this process, and recent genetic association studies po...
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Protocol
The Emerging Role of Metalloproteomics in Alzheimer’s Disease Research
Metals are increasingly recognized to have an important role in molecular processes underlying Alzheimer’s disease (AD). This chapter discusses the current role of metals in AD and expands on the development o...
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Article
Open AccessAlzheimer’s disease cerebrospinal fluid biomarkers are not influenced by gravity drip or aspiration extraction methodology
Cerebrospinal fluid (CSF) biomarkers, although of established utility in the diagnostic evaluation of Alzheimer’s disease (AD), are known to be sensitive to variation based on pre-analytical sample processing....
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Article
Open AccessFollow-up plasma apolipoprotein E levels in the Australian Imaging, Biomarkers and Lifestyle Flagship Study of Ageing (AIBL) cohort
Alzheimer’s disease (AD) is a growing socioeconomic problem worldwide. Early diagnosis and prevention of this devastating disease have become a research priority. Consequently, the identification of clinically...
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Article
The search for a blood-based biomarker for Alzheimer disease
Finding a peripheral biomarker for early Alzheimer disease (AD) is a major challenge. A recent study has validated a plasma protein signature that is associated with mild cognitive impairment and AD, and could...
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Article
Oligomers, fact or artefact? SDS-PAGE induces dimerization of β-amyloid in human brain samples
The formation of low-order oligomers of β-amyloid (Aβ) within the brain is widely believed to be a central component of Alzheimer’s disease (AD) pathogenesis. However, despite advances in high-throughput and h...
