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Article
Tissue-specific thresholds of mutation burden associated with anti-PD-1/L1 therapy benefit and prognosis in microsatellite-stable cancers
Immune checkpoint inhibitors (ICIs) targeting programmed cell death protein 1 or its ligand (PD-1/L1) have expanded the treatment landscape against cancers but are effective in only a subset of patients. Tumor...
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Article
Open AccessPBRM1 mutations might render a subtype of biliary tract cancers sensitive to drugs targeting the DNA damage repair system
Polybromo-1 (PBRM1) loss of function mutations are present in a fraction of biliary tract cancers (BTCs). PBRM1, a subunit of the PBAF chromatin-remodeling complex, is involved in DNA damage repair. Herein, we ai...
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Article
Open AccessSex hormones influence survival of patients with metastatic urothelial carcinoma undergoing immune checkpoint therapy
Clinical trials investigating efficacy of immune checkpoint inhibitors (ICI) revealed sex-specific divergent outcomes in urothelial cancer (UC), suggesting that sex hormones might play an important role in gen...
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Article
Molecular profiling of signet-ring-cell carcinoma (SRCC) from the stomach and colon reveals potential new therapeutic targets
Signet ring cell carcinoma (SRCC) is rare: about 10% of gastric cancer (GC) and 1% of colorectal cancer (CRC). SRCC is associated with poor prognosis, however the underlying molecular characteristics are unkno...
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Article
Open AccessRare lung cancers—Primary pulmonary leiomyosarcoma: A case report
Primary pulmonary sarcomas (PPS) are rare mesenchymal lung cancers, which do not present clinically or radiological different to lung carcinomas. Definite PPS diagnosis can only be made by histological analysi...
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Article
Open AccessMolecular differences between lymph nodes and distant metastases compared with primaries in colorectal cancer patients
Lymph nodes (LNs) and distant metastases can arise from independent subclones of the primary tumor. Herein, we characterized the molecular landscape and the differences between LNs, distant metastases and prim...
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Article
Large-scale analysis of KMT2 mutations defines a distinctive molecular subset with treatment implication in gastric cancer
Frequent mutations of genes in the histone-lysine N-methyltransferase 2 (KMT2) family members were identified in gastric cancers (GCs). Understanding how gene mutations of KMT2 family affect cancer progression an...
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Living Reference Work Entry In depth
Organtoxizität antineoplastischer Substanzen
Neben der Effektivität antineoplastischer Therapien spielen therapieassoziierte Toxizitäten in der Behandlung von Tumorpatienten eine wichtige Rolle. Die rasante Entwicklung in der Onkologie mit einer Vielzahl...
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Article
Open AccessCost-comparison analysis of a multiplatform tumour profiling service to guide advanced cancer treatment
Tumor profiling is increasingly used in advanced cancer patients to define treatment options, especially in refractory cases where no standard treatment is available. Caris Molecular Intelligence (CMI) is a mu...
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Article
Open AccessResistance in gastrointestinal stromal tumors
The approval of imatinib for the treatment of patients with gastrointestinal stromal tumor has (GIST) revolutionized the treatment in the adjuvant setting and metastatic disease. Imatinib is an inhibitor of th...
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Article
Open AccessSoluble EpCAM levels in ascites correlate with positive cytology and neutralize catumaxomab activity in vitro
EpCAM is highly expressed on membrane of epithelial tumor cells and has been detected as soluble/secreted (sEpCAM) in serum of cancer patients. In this study we established an ELISA for in vitro diagnostics to me...
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Article
Occupational styrene exposure and neurobehavioural functions: a cohort study with repeated measurements
Associations between occupational styrene exposure and cognitive as well as psychomotor functions were investigated with a view to answering three questions: (1) are the published results for neurobehavioural ...
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Article
Occupational styrene exposure, colour vision and contrast sensitivity: a cohort study with repeated measurements
Associations between occupational styrene exposures and impairment of visual functions were investigated with a view to answering three questions: (1) are the published findings for colour vision deficiencies ...
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Article
Occupational styrene exposure and hearing loss: a cohort study with repeated measurements
Associations between occupational styrene exposure and impairment of hearing function were investigated, guided by three questions: are there hearing losses concerning high frequency and standard audiometric t...
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Chapter and Conference Paper
Neurobehavioral Tests as Evaluation of Neurotoxically Induced Impairments of Health
The multidisciplinary approach of ergonomics covers conceptions aiming at the prevention of harmful effects due to chemical exposure. There are general recommendations to avoid exposure related annoyances, imp...
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Article
Neurobehavioural test results and exposure to inorganic mercury: in search of dose-response relations
The aim of the analysis was, in general, to find a way to summarise results of studies in search of exposure-response relationships and, in particular, to ask whether an exposure-response relationship can be a...
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Article
Toluene exposure below 50 ppm and cognitive function: a follow-up study with four repeated measurements in rotogravure printing plants
There are findings of cross-sectional studies on slight cognitive effects due to toluene exposure below 50 ppm. The critical points of the earlier studies will be scrutinised by a follow-up study with four exa...
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Article
Psychological reactions related to chemosensory irritation
Objectives: For risk assessments of solvents the knowledge on chemosensory irritation effects is important, but the methodological base for that is incomplete. The psychological approach...
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Article
A summary of two meta-analyses on neurobehavioural effects due to occupational lead exposure
The conclusions from published results about neurotoxic effects of inorganic lead exposures <700 µg lead/l blood are contradictory at present. Effects measured by neurobehavioural methods are evaluated differ...
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Article
A meta-analysis for neurobehavioural results due to occupational mercury exposure
A meta-analysis for neurobehavioural test results of subjects occupationally exposed to mercury was carried out in order to find general tendencies and express possible deficits numerically. Out of 44 studies...
