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Article
Molecular basis for nuclear accumulation and targeting of the inhibitor of apoptosis BIRC2
The inhibitor of apoptosis protein BIRC2 regulates fundamental cell death and survival signaling pathways. Here we show that BIRC2 accumulates in the nucleus via binding of its second and third BIR domains, BIRC2
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Article
Open AccessCorrection: DNA damage and S phase-dependent E2F1 stabilization requires the cIAP1 E3-ubiquitin ligase and is associated with K63-poly-ubiquitination on lysine 161/164 residues
Correction to:Cell Death & Disease8, e2816 (2017); https://doi.org/10.1038/cddis.2017.222; published online 25 May 2017.
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Article
Open AccessInvestigation into the role of the germline epigenome in the transmission of glucocorticoid-programmed effects across generations
Early life exposure to adverse environments affects cardiovascular and metabolic systems in the offspring. These programmed effects are transmissible to a second generation through both male and female lines, ...
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Article
Open AccessDNA damage and S phase-dependent E2F1 stabilization requires the cIAP1 E3-ubiquitin ligase and is associated with K63-poly-ubiquitination on lysine 161/164 residues
The E2F transcription factor 1 is subtly regulated along the cell cycle progression and in response to DNA damage by post-translational modifications. Here, we demonstrated that the E3-ubiquitin ligase cellula...
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Article
New IDH1 mutant inhibitors for treatment of acute myeloid leukemia
Gain of function mutations in isocitrate dehydrogenase 1 (IDH1) have been detected in cases of acute myeloid leukemia (AML). The application of an allosteric IDH1 inhibitor in AML cells promotes blast differen...
