5 Result(s)
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Chapter and Conference Paper
Generator Platform of Benchmark Time-Lapsed Images Development of Cell Tracking Algorithms: Implementation of New Features Towards a Realistic Simulation of the Cell Spatial and Temporal Organization
Recent developments in live-cell microscopy imaging have led to the emergence of Single Cell Biology. This field has also been supported by the development of cell segmentation and tracking algorithms for dat...
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Chapter and Conference Paper
Estimating Effects of Extrinsic Noise on Model Genes and Circuits with Empirically Validated Kinetics
Recent studies of Escherichia coli transcription dynamics using time-lapse confocal microscopy and in vivo single-RNA detection confirmed that transcription initiation has two main rate-limiting steps. Here, we a...
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Chapter and Conference Paper
Modeling and Engineering Promoters with Pre-defined RNA Production Dynamics in Escherichia Coli
Recent developments in live-cell time-lapse microscopy and signal processing methods for single-cell, single-RNA detection now allow characterizing the in vivo dynamics of RNA production of Escherichia coli promo...
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Chapter
Evolutionary Dynamics of a Population of Cells with a Toxin Suppressor Gene
Environmental changes are known to trigger evolutionary changes, e.g. by favoring higher mutation rates. We study the evolutionary dynamics of a delayed stochastic genetic circuit using a simulator developed f...
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Chapter
Information Propagation in the Long-Term Behavior of Gene Regulatory Networks
Gene regulatory networks (GRNs) constantly receive, process and send information. While stochastic in nature, GRNs respond differently to different inputs and similarly to identical inputs. Since cell types st...
