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Article
Dysregulated Wnt/β-catenin signaling confers resistance to cuproptosis in cancer cells
Cuproptosis is characterized by the aggregation of lipoylated enzymes of the tricarboxylic acid cycle and subsequent loss of iron-sulfur cluster proteins as a unique copper-dependent form of regulated cell dea...
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Article
Differential surface microbial community and thalli metabolome as early indicators of disease in red algae Pyropia yezoensis
To understand pathogenic mechanisms and suggest molecular biomarker candidates for the disease status of edible red algae, Pyropia, we analyzed relationships between disease symptom severity, changes in microbial...
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Article
Study on the Influence of Annealing and Ball Milling on the Magnetic Properties of HDDR Nd-Fe-B Magnetic Powder
The Nd-Fe-B anisotropic magnetic powders were subjected to tempering and ball milling processes. Analysis of the magnetic properties, structure, and physical phase revealed that the following: the integrated m...
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Article
A vertical Sato-Tate law for GL(4)
We establish a doubly-weighted vertical Sato-Tate law for GL(4) with explicit error terms. The main ingredient is an extension of the orthogonality relation for Maass cusp forms on GL(4) of Goldfeld, Stade, an...
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Article
The density of the graph of elliptic Dedekind sums
We show that the graph of normalized elliptic Dedekind sums is dense in its image for arbitrary imaginary quadratic fields, generalizing a result of Ito in the Euclidean case. We also derive some basic propert...
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Article
Disruption of DNA-PKcs-mediated cGAS retention on damaged chromatin potentiates DNA damage-inducing agent-induced anti-multiple myeloma activity
Targeting DNA damage repair factors, such as DNA-dependent protein kinase catalytic subunit (DNA-PKcs), may offer an opportunity for effective treatment of multiple myeloma (MM). In combination with DNA damage...
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Article
Exploring the Mechanism of Subjective Social Status on Compulsive Shop** Behavior: A Moderated Mediation Model of Self-compassion and Depression
The present study aimed to explore the mediating role of depression in the relationship between subjective social status (SSS) and compulsive shop** behavior (CSB) and whether self-compassion (SC) played a m...
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Article
Open AccessChildren’s Social, Emotional, and Behavioral Outcomes in Military Families: A Rapid Review
In light of ongoing global military conflicts, including the Israel-Hamas war and the Russia-Ukraine war, it is imperative to study the effects of parental military service and deployment on the health and wel...
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Article
Performance of multisite streamflow stochastic generation approaches for a multi-reservoir system
The streamflow process is an crucial information resource for the joint optimal operation of reservoirs. As the length and representativeness of historical streamflow samples are insufficient for practice proj...
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Article
Open AccessOutcomes of Best-Practice Guided Digital Mental Health Interventions for Youth and Young Adults with Emerging Symptoms: Part II. A Systematic Review of User Experience Outcomes
Although many young people demonstrate resilience and strength, research and clinical evidence highlight an upward trend in mental health concerns among those aged 12 to 25 years. Youth-specific digital mental...
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Article
A Review on Nanosystem-Based Delivery of Tofacitinib for Enhanced Treatment of Autoimmune Diseases and Inflammation
Tofacitinib is the first Janus kinase inhibitor approved by the United States Food and Drug Administration to manage rheumatoid arthritis, psoriatic arthritis, ulcerative colitis, and polyarticular course juve...
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Article
Discerning the effect of operating conditions on the improvement of up-flow constructed wetland-microbial fuel cell performance in treating mixed azo dyes wastewater and bioelectricity generation
This study assessed the effect of implementing multiple circuit connections and operating parameters (hydraulic retention time (HRT), organic loading rate (OLR), and external resistance) on the improvement of ...
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Article
Open AccessOutcomes of Best-Practice Guided Digital Mental Health Interventions for Youth and Young Adults with Emerging Symptoms: Part I. A Systematic Review of Socioemotional Outcomes and Recommendations
Youth-specific digital mental health interventions (DMHI) represent an emerging field of study, and aim to increase access, improve socioemotional outcomes, and, where required, support triage to targeted inte...
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Article
Open AccessmsBERT-Promoter: a multi-scale ensemble predictor based on BERT pre-trained model for the two-stage prediction of DNA promoters and their strengths
A promoter is a specific sequence in DNA that has transcriptional regulatory functions, playing a role in initiating gene expression. Identifying promoters and their strengths can provide valuable information ...
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Article
Improvement of Corrosion and Wear Resistance of Mg-Li Alloy by Binary- and Ternary-Layered Double Hydroxide/Steam Coating Composite Coatings
In order to improve the corrosion resistance and frictional wear resistance of LA43M Mg-Li alloy, Mg-Al-layered double hydroxide (LDH)/steam coating (SC) and Mg-Al-Co LDH/SC composite coatings were prepared on...
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Article
Open AccessEnhancement of phase transition temperature through hydrogen bond modification in molecular ferroelectrics
Molecular ferroelectrics are attracting great interest due to their light weight, mechanical flexibility, low cost, ease of processing and environmental friendliness. These advantages make molecular ferroelect...
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Article
Open AccessThe 90% effective dose (ED90) of remimazolam for inhibiting responses to the insertion of a duodenoscope during ERCP
Compared to midazolam, remimazolam has a faster onset and offset of hypnotic effect, as well as cardiorespiratory stability, this study aims to determine the 90% effective dose (ED90) of remimazolam to inhibit...
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Article
Open Accessm1A inhibition fuels oncolytic virus-elicited antitumor immunity via downregulating MYC/PD-L1 signaling
N1-methyladenosine (m1A) RNA methylation is critical for regulating mRNA translation; however, its role in the development, progression, and immunotherapy response of head and neck squamous cell carcinoma (HNSCC)...
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Article
Discrete-Velocity-Direction Models of BGK-Type with Minimum Entropy: II—Weighted Models
In this series of works, we develop a discrete-velocity-direction model (DVDM) with collisions of BGK-type for simulating gas flows, where the molecular motion is confined to some prescribed directions but the...
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Article
Open AccessFn-OMV potentiates ZBP1-mediated PANoptosis triggered by oncolytic HSV-1 to fuel antitumor immunity
Oncolytic viruses (OVs) show promise as a cancer treatment by selectively replicating in tumor cells and promoting antitumor immunity. However, the current immunogenicity induced by OVs for tumor treatment is ...
