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Article
Efficient AID targeting of switch regions is not sufficient for optimal class switch recombination
Antibody affinity maturation relies on activation-induced cytidine deaminase (AID)-dependent somatic hypermutation (SHM) of immunoglobulin (Ig) loci. Class switch recombination (CSR) can in parallel occur betw...
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Protocol
Immunophenoty** of the Medullary B Cell Compartment In Mouse Models
B cell development is a stepwise process encompassing several B cell precursor stages that can be phenotypically distinguished, and that is taking place in the bone marrow in adults. Interestingly, within the ...
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Article
Open AccessWHIM Syndrome-linked CXCR4 mutations drive osteoporosis
WHIM Syndrome is a rare immunodeficiency caused by gain-of-function CXCR4 mutations. Here we report a decrease in bone mineral density in 25% of WHIM patients and bone defects leading to osteoporosis in a WHIM mo...