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  1. Article

    Open Access

    WHIM Syndrome-linked CXCR4 mutations drive osteoporosis

    WHIM Syndrome is a rare immunodeficiency caused by gain-of-function CXCR4 mutations. Here we report a decrease in bone mineral density in 25% of WHIM patients and bone defects leading to osteoporosis in a WHIM mo...

    Adrienne Anginot, Julie Nguyen, Zeina Abou Nader, Vincent Rondeau… in Nature Communications (2023)

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    Immunophenoty** of the Medullary B Cell Compartment In Mouse Models

    B cell development is a stepwise process encompassing several B cell precursor stages that can be phenotypically distinguished, and that is taking place in the bone marrow in adults. Interestingly, within the ...

    Amélie Bonaud, Karl Balabanian, Marion Espéli in Bone Marrow Environment (2021)

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    Article

    Efficient AID targeting of switch regions is not sufficient for optimal class switch recombination

    Antibody affinity maturation relies on activation-induced cytidine deaminase (AID)-dependent somatic hypermutation (SHM) of immunoglobulin (Ig) loci. Class switch recombination (CSR) can in parallel occur betw...

    Amélie Bonaud, Fabien Lechouane, Sandrine Le Noir… in Nature Communications (2015)