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  1. Article

    Open Access

    IRF4 deficiency vulnerates B-cell progeny for leukemogenesis via somatically acquired Jak3 mutations conferring IL-7 hypersensitivity

    The processes leading from disturbed B-cell development to adult B-cell progenitor acute lymphoblastic leukemia (BCP-ALL) remain poorly understood. Here, we describe Irf4−/− mice as prone to develo** BCP-ALL wi...

    Dennis Das Gupta, Christoph Paul, Nadine Samel in Cell Death & Differentiation (2022)

  2. Article

    Induction of robust cellular and humoral immunity against SARS-CoV-2 after a third dose of BNT162b2 vaccine in previously unresponsive older adults

    Here we compared SARS-CoV-2-specific antibody and T-cell responses between older adults (>80 years old, n = 51) and a younger control group (20–53 years old, n = 46) after receiving two doses of BNT162b2. We foun...

    Addi J. Romero-Olmedo, Axel Ronald Schulz, Svenja Hochstätter in Nature Microbiology (2022)