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Article
Establishing African genomics and bioinformatics programs through annual regional workshops
The African BioGenome Project (AfricaBP) Open Institute for Genomics and Bioinformatics aims to overcome barriers to capacity building through its distributed African regional workshops and prioritizes the exc...
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Article
Open AccessAntibody escape and global spread of SARS-CoV-2 lineage A.27
In spring 2021, an increasing number of infections was observed caused by the hitherto rarely described SARS-CoV-2 variant A.27 in south-west Germany. From December 2020 to June 2021 this lineage has been dete...
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Article
Open AccessAuthor Correction: High-depth African genomes inform human migration and health
A Correction to this paper has been published: https://doi.org/10.1038/s41586-021-03286-9.
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Article
Open AccessHigh-quality genome sequence assembly of R.A73 Enterococcus faecium isolated from freshwater fish mucus
Whole-genome sequencing using high throughput technologies has revolutionized and speeded up the scientific investigation of bacterial genetics, biochemistry, and molecular biology. Lactic acid bacteria (LABs)...
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Article
High-depth African genomes inform human migration and health
The African continent is regarded as the cradle of modern humans and African genomes contain more genetic variation than those from any other continent, yet only a fraction of the genetic diversity among Afric...
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Chapter and Conference Paper
Separators for Polynomial Dynamic Systems with Linear Complexity
Computation biology helps to understand processes in organisms from interaction of molecules to complex functions of whole organs. Therefore, there is a need for mathematical methods and models that deliver l...
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Open AccessIn silico prediction of protein-protein interactions in human macrophages
Protein-protein interaction (PPI) network analyses are highly valuable in deciphering and understanding the intricate organisation of cellular functions. Nevertheless, the majority of available protein-protein...
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Article
Open AccessMethodology optimizing SAGE library tag-to-gene map**: application to Leishmania
Leishmaniasis are widespread parasitic-diseases with an urgent need for more active and less toxic drugs and for effective vaccines. Understanding the biology of the parasite especially in the context of host ...
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Article
Open AccessBasal DNA repair machinery is subject to positive selection in ionizing-radiation-resistant bacteria
Ionizing-radiation-resistant bacteria (IRRB) show a surprising capacity for adaptation to ionizing radiation and desiccation. Positive Darwinian selection is expected to play an important role in this trait, b...
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Open AccessSimultaneous gene expression profiling in human macrophages infected with Leishmania major parasites using SAGE
Leishmania (L) are intracellular protozoan parasites that are able to survive and replicate within the harsh and potentially hostile phagolysosomal environment of mammalian mononuclear phagocytes. A complex inter...
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Article
Open AccessCross-species hybridisation of human and bovine orthologous genes on high density cDNA microarrays
Cross-species gene-expression comparison is a powerful tool for the discovery of evolutionarily conserved mechanisms and pathways of expression control. The usefulness of cDNA microarrays in this context is th...
