10 Result(s)
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Alexander V Ratushny
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Article
Open AccessAnalysis of cellular kinetic models suggest that physiologically based model parameters may be inherently, practically unidentifiable
Physiologically-based pharmacokinetic and cellular kinetic models are used extensively to predict concentration profiles of drugs or adoptively transferred cells in patients and laboratory animals. Models are ...
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Article
Correction to: Quantitative Systems Pharmacology Modeling of Avadomide-Induced Neutropenia Enables Virtual Clinical Dose and Schedule Finding Studies
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Article
Open AccessQuantitative Systems Pharmacology Modeling of Avadomide-Induced Neutropenia Enables Virtual Clinical Dose and Schedule Finding Studies
Avadomide is a cereblon E3 ligase modulator and a potent antitumor and immunomodulatory agent. Avadomide trials are challenged by neutropenia as a major adverse event and a dose-limiting toxicity. Intermittent...
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Article
Open AccessGenetic program activity delineates risk, relapse, and therapy responsiveness in multiple myeloma
Despite recent advancements in the treatment of multiple myeloma (MM), nearly all patients ultimately relapse and many become refractory to multiple lines of therapies. Therefore, we not only need the ability ...
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Chapter
On the Potential for Multiscale Oscillatory Behavior in HIV
This chapter summarizes several theoretical studies on the potential for oscillatory behavior of HIV infection at molecular and cellular levels. It discusses the biological relevance of oscillatory systems in ...
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Article
Correction: Corrigendum: Pan-viral specificity of IFN-induced genes reveals new roles for cGAS in innate immunity
Nature 505, 691–695 (2014); doi:10.1038/nature12862 In this Letter, we carried out bioinformatic analyses on interferon-stimulated gene screening data sets for multiple viruses, including a data set for West N...
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Article
Open AccessBicluster Sampled Coherence Metric (BSCM) provides an accurate environmental context for phenotype predictions
Biclustering is a popular method for identifying under which experimental conditions biological signatures are co-expressed. However, the general biclustering problem is NP-hard, offering room to focus algorit...
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Article
Pan-viral specificity of IFN-induced genes reveals new roles for cGAS in innate immunity
The specificity of interferon effectors across an expanded range of viruses is studied, with results indicating that positive-sense single-stranded RNA viruses are more susceptible to interferon-stimulated gen...
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Article
A FOXO3–IRF7 gene regulatory circuit limits inflammatory sequelae of antiviral responses
FOXO3 is a negative regulator of IRF7, a master regulator of the antiviral response.
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Protocol
Mathematical Modeling of Biomolecular Network Dynamics
Mathematical and computational models have become indispensable tools for integrating and interpreting heterogeneous biological data, understanding fundamental principles of biological system functions, genera...
