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Article
Open AccessAddressing barriers in FAIR data practices for biomedical data
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Article
Open AccessA single-cell based precision medicine approach using glioblastoma patient-specific models
Glioblastoma (GBM) is a heterogeneous tumor made up of cell states that evolve over time. Here, we modeled tumor evolutionary trajectories during standard-of-care treatment using multi-omic single-cell analysi...
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Article
Open AccessGenetic program activity delineates risk, relapse, and therapy responsiveness in multiple myeloma
Despite recent advancements in the treatment of multiple myeloma (MM), nearly all patients ultimately relapse and many become refractory to multiple lines of therapies. Therefore, we not only need the ability ...
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Article
Open AccessTranscriptional program for nitrogen starvation-induced lipid accumulation in Chlamydomonas reinhardtii
Algae accumulate lipids to endure different kinds of environmental stresses including macronutrient starvation. Although this response has been extensively studied, an in depth understanding of the transcripti...
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Article
Open AccessA comprehensive map of genome-wide gene regulation in Mycobacterium tuberculosis
Mycobacterium tuberculosis (MTB) is a pathogenic bacterium responsible for 12 million active cases of tuberculosis (TB) worldwide. The complexity and critical regulatory components of MTB pathogenicity are still ...
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Article
Open AccessThe DNA-binding network of Mycobacterium tuberculosi s
Mycobacterium tuberculosis (MTB) infects 30% of all humans and kills someone every 20–30 s. Here we report genome-wide binding for ~80% of all predicted MTB transcription factors (TFs), and assayed global express...
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Article
Open AccessMap** and manipulating the Mycobacterium tuberculosis transcriptome using a transcription factor overexpression-derived regulatory network
Mycobacterium tuberculosis senses and responds to the shifting and hostile landscape of the host. To characterize the underlying intertwined gene regulatory network governed by approximately 200 transcription fac...
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Chapter
Biogenesis of c-type Cytochromes and Cytochrome Complexes
In most anoxygenic phototrophic bacteria, apocytochromes c are synthesized in the cytoplasm, translocated across the membrane and matured to holocytochromes c on the periplasmic side. The extracytoplasmic maturat...
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Chapter
Photobiological Hydrogen Production by Rhodobacter sphaeroides O.U.001 by Utilization of Waste Water from Milk Industry
Hydrogen production with photosynthetic microorganisms contributes to the protection of the environment, not only in producing a clean fuel but also in waste treatment processes. In this study, Rhodobacter sphaer...
