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Open AccessModeling the limits of detection for antimicrobial resistance genes in agri-food samples: a comparative analysis of bioinformatics tools
Although the spread of antimicrobial resistance (AMR) through food and its production poses a significant concern, there is limited research on the prevalence of AMR bacteria in various agri-food products. Seq...
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Open AccessTetanus in a vaccinated soil expert - a case report
Tetanus is a life-threatening vaccine-preventable disease found more commonly in tropical climates. It accounted for up to 60 deaths annually until the introduction of the tetanus toxoid. It is now rare in Can...
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Article
Correction: Association between pre‑treatment chest imaging and pulmonary function abnormalities and immune checkpoint inhibitor pneumonitis
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Open AccessCollateral sensitivity profiling in drug-resistant Escherichia coli identifies natural products suppressing cephalosporin resistance
The rapid emergence of antimicrobial resistance presents serious health challenges to the management of infectious diseases, a problem that is further exacerbated by slowing rates of antimicrobial drug discove...
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Article
Open AccessSpatial map** of mitochondrial networks and bioenergetics in lung cancer
Mitochondria are critical to the governance of metabolism and bioenergetics in cancer cells1. The mitochondria form highly organized networks, in which their outer and inner membrane structures define their bioen...
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Article
Open AccessCorrection to: Near-term climate risks and solar radiation modification: a roadmap approach for physical sciences research
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Open AccessNear-term climate risks and sunlight reflection modification: a roadmap approach for physical sciences research
Current impacts and escalating risks of climate change require strong and decisive action to reduce greenhouse gas (GHG) emissions. They also highlight the urgency of research to enhance safety for human and n...
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Open AccessExperiences and Perspectives of Patients with Non-HIV-Associated Lipodystrophies and Their Caregivers: A Qualitative Study
Lipodystrophy comprises a group of conditions characterized by loss of functional adipose tissue, resulting in severe metabolic complications and a complex range of symptoms.
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Open AccessPost-gel polymerisation shrinkage profiling of polymer biomaterials using a chirped fibre Bragg grating
A strain profile measurement technique using a chirped fibre Bragg grating (CFBG) sensor by implementing an integration of differences (IOD) method is reported in this paper. Using the IOD method the spatial d...
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Article
Governing antimicrobial resistance: a narrative review of global governance mechanisms
Antimicrobial resistance (AMR), a central health challenge of the twenty first century, poses substantial population health risks, with deaths currently estimated to be around 700,000 per year globally. The in...
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Open AccessCharacteristics and outcomes of antiretroviral-treated HIV-HBV co-infected patients in Canada
Hepatitis B (HBV) and Human Immunodeficiency Virus (HIV) share common risk factors for exposure. Co-infected patients have an increased liver-related mortality risk and may have accelerated HIV progression. Th...
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Article
Open AccessLipid accumulation facilitates mitotic slippage-induced adaptation to anti-mitotic drug treatment
Aberrant lipid accumulation is a hallmark of cancer known to contribute to its aggressiveness and malignancy. Emerging studies have demonstrated context-dependent changes in lipid metabolism during chemotherap...
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Article
The Differential Binding of Antipsychotic Drugs to the ABC Transporter P-Glycoprotein Predicts Cannabinoid–Antipsychotic Drug Interactions
Cannabis use increases rates of psychotic relapse and treatment failure in schizophrenia patients. Clinical studies suggest that cannabis use reduces the efficacy of antipsychotic drugs, but there has been no ...
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Open AccessHigh-quality genome assembly of channel catfish, Ictalurus punctatus
The channel catfish (Ictalurus punctatus), a species native to North America, is one of the most important commercial freshwater fish in the world, especially in the United States’ aquaculture industry. Since its...
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Open AccessFish-T1K (Transcriptomes of 1,000 Fishes) Project: large-scale transcriptome data for fish evolution studies
Ray-finned fishes (Actinopterygii) represent more than 50 % of extant vertebrates and are of great evolutionary, ecologic and economic significance, but they are relatively underrepresented in ‘omics studies. ...
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Open AccessDraft genome of the Chinese mitten crab, Eriocheir sinensis
The Chinese mitten crab, Eriocheir sinensis, is one of the most studied and economically important crustaceans in China. Its transition from a swimming to a crawling method of movement during early development, a...
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Article
Open AccessEfficient prediction of human protein-protein interactions at a global scale
Our knowledge of global protein-protein interaction (PPI) networks in complex organisms such as humans is hindered by technical limitations of current methods.
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Article
Open AccessDifferential gene expression in mouse primary hepatocytes exposed to the peroxisome proliferator-activated receptor α agonists
Fibrates are a unique hypolipidemic drugs that lower plasma triglyceride and cholesterol levels through their action as peroxisome proliferator-activated receptor alpha (PPARα) agonists. The activation of PPAR...
