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  1. No Access

    Article

    Decreased alertness due to sleep loss increases pain sensitivity in mice

    In mice, sleep loss increases sensitivity to painful stimuli. Restoration of normal sleep or acute treatment with wake-promoting agents can normalize pain sensitivities.

    Chloe Alexandre, Alban Latremoliere, Ashley Ferreira, Giulia Miracca… in Nature Medicine (2017)

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    Article

    The serine protease inhibitor SerpinA3N attenuates neuropathic pain by inhibiting T cell–derived leukocyte elastase

    Inhibition of T cell–derived leukocyte elastase by neuronal SerpinA3N or the drug Sivelestat reduces neuropathic pain.

    Lucas Vicuña, David E Strochlic, Alban Latremoliere, Kiran Kumar Bali… in Nature Medicine (2015)