10 Result(s)

Article

Otherworldly Properties

Despite the many differing perspectives possible regarding the concept of a property right, one central aspect is, arguably, the primal exclusionary impulse and its special connection to a particular form of s...

Alan Cunningham in Law and Critique (2024)

Article

Neuro-ophthalmology in the United Kingdom: providing a sustainable, safe and high-quality service for the future

Susan P. Mollan, Vaishnavi Menon, Alan Cunningham, Gordon T. Plant, Luke Bennetto… in Eye (2024)

Article

Inhibition of the succinyl dehydrogenase complex in acute myeloid leukemia leads to a lactate-fuelled respiratory metabolic vulnerability

Metabolic programs can differ substantially across genetically distinct subtypes of acute myeloid leukemia (AML). These programs are not static entities but can change swiftly as a consequence of extracellular...

Ayşegül Erdem, Silvia Marin, Diego A. Pereira-Martins… in Nature Communications (2022)

Article

The Glycolytic Gatekeeper PDK1 defines different metabolic states between genetically distinct subtypes of human acute myeloid leukemia

Acute myeloid leukemia remains difficult to treat due to strong genetic heterogeneity between and within individual patients. Here, we show that Pyruvate dehydrogenase kinase 1 (PDK1) acts as a targetable dete...

Ayşegül Erdem, Silvia Marin, Diego A. Pereira-Martins… in Nature Communications (2022)

Article

HIF1/2-exerted control over glycolytic gene expression is not functionally relevant for glycolysis in human leukemic stem/progenitor cells

Hypoxia-inducible factors (HIF)1 and 2 are transcription factors that regulate the homeostatic response to low oxygen conditions. Since data related to the importance of HIF1 and 2 in hematopoietic stem and pr...

Albertus T. J. Wierenga, Alan Cunningham, Ayşegül Erdem… in Cancer & Metabolism (2019)

Article

A long history of dense deposit disease

Dense Deposit Disease is a rare condition affecting the Bruch’s membrane and the glomerular basement membrane. We report the progression of the ocular manifestations over a 30 year follow up period, longer tha...

Alan Cunningham, Ajay Kotagiri in BMC Ophthalmology (2018)

Article

Antagonizing Retinoic Acid Receptors Increases Myeloid Cell Production by Cultured Human Hematopoietic Stem Cells

Activities of the retinoic acid receptor (RAR)α and RARγ are important to hematopoiesis. Here, we have investigated the effects of receptor selective agonists and antagonists on the primitive human hematopoiet...

Geoffrey Brown, Aleksandra Marchwicka… in Archivum Immunologiae et Therapiae Experim… (2017)

Article

Floral Initiation of Xanthium in Response to Application of an Extract from a Day-Neutral Plant

A PROCEDURE for the preparation of a floral initiating extract from the leaf tissues of Xanthium strumarium has been described in an earlier report¹. In general, the procedure involves the rapid freezing in liqui...

RICHARD G. LINCOLN, DARWIN L. MAYFIELD, ROBERT O. HUTCHINS, ALAN CUNNINGHAM… in Nature (1962)