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Article
In vitro drug screening models derived from different PC12 cell lines for exploring Parkinson’s disease based on electrochemical signals of catecholamine neurotransmitters
Gold nanostructures and a Nafion modified screen-printed carbon electrode (Nafion/AuNS/SPCE) were developed to assess the cell viability of Parkinson’s disease (PD) cell models. The electrochemical measuremen...
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Article
Drinking water quality evaluation in supply systems in Wuhan, China: application of entropy weight water quality index and multivariate statistical analysis
In this study, source water, finished water, and tap water were sampled monthly from two large drinking water treatment plants in Wuhan city, China for 12 months where physicochemical and microbiological param...
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Article
An electrochemiluminescence resonance energy transfer biosensor based on CDs/PAMAM/rGO nanocomposites and Au@Ag2S nanoparticles for PML/RARα fusion gene detection
In recent years, electrochemiluminescence resonance energy transfer (ECL-RET) with low background signal and high specificity has attracted much attention among researchers. Herein, we established a novel ECL-...
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Article
Using Pgst-4::GFP-transformed Caenorhabditis elegans for drinking water quality monitoring
Biological effect-based monitoring is essential for predicting or alerting to a possible deterioration in drinking water quality. In the present study, a reporter gene assay based on oxidative stress–mediated Pgs...
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Article
Toxicological characteristics of drinking water in two large-scale municipal water supply systems of a metropolitan city in Central China
Drinking water safety is threatened by numerous toxic organic pollutants difficult to chemically monitor. This study aimed to determine the toxicological profiles of organic extracts (OEs) of water samples fro...
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Article
Altered Retinal Dopamine Levels in a Melatonin-proficient Mouse Model of Form-deprivation Myopia
Reduced levels of retinal dopamine, a key regulator of eye development, are associated with experimental myopia in various species, but are not seen in the myopic eyes of C57BL/6 mice, which are deficient in m...
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Article
Comparative and Combined Effects of Epigallocatechin-3-gallate and Caffeine in Reducing Lipid Accumulation in Caenorhabditis elegans
Epigallocatechin-3-gallate (EGCG) and caffeine, two phytochemicals found in a wide range of natural dietary sources, have been reported to have protective effects against hyperlipidemia, a major risk factor fo...
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Article
DL0410 ameliorates cognitive disorder in SAMP8 mice by promoting mitochondrial dynamics and the NMDAR-CREB-BDNF pathway
Alzheimer’s disease (AD) is a worldwide problem and there are no effective drugs for AD treatment. Previous studies show that DL0410 is a multi-target, anti-AD agent. In this study, we investigated the therape...
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Article
A high-performance amperometric sensor based on a monodisperse Pt–Au bimetallic nanoporous electrode for determination of hydrogen peroxide released from living cells
A neotype electrochemical sensor based on a three-dimensional nanoporous gold (3D-NPG) electrode decorated with ultra-thin platinum nanoparticles (Pt NPs) was fabricated for high-performance electrocatalysis a...
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Article
DL0410 ameliorates cognitive deficits in APP/PS1 transgenic mice by promoting synaptic transmission and reducing neuronal loss
At present, few available drugs can be used to either improve pathological features or prevent the progression of Alzheimer’s disease (AD). DL0410 ((1,1′-([1,1′-biphenyl]-4,4′-diyl) bis (3-(piperidin-1-yl) propan...
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Article
Highly sensitive colorimetric sensor for detection of iodine ions using carboxylated chitosan–coated palladium nanozyme
Although a massive research has been devoted on the exploration of noble metal–based nanozyme, less progress has been made in the investigation of palladium (Pd) nanozyme and the interaction between ions and P...
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Article
Improved enzymatic assay for hydrogen peroxide and glucose by exploiting the enzyme-mimicking properties of BSA-coated platinum nanoparticles
Platinum nanoparticles (Pt NPs) covered with a bovine serum albumin scaffold and a particle size of 1.5 nm (BSA-PtS NPs) are shown to display enhanced multiple enzyme-mimicking activities including peroxidase, ox...
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Article
Anti-influenza effect and action mechanisms of the chemical constituent gallocatechin-7-gallate from Pithecellobium clypearia Benth
Host cdc2-like kinase 1 (CLK1) is responsible for the alternative splicing of the influenza virus M2 gene during influenza virus infection and replication that has been recognized as a potential anti-influenza...
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Chapter
Bergenin
Bergenin is a kind of lactone mainly extracted from the Chinese cabbage plant. It has antipyretic, analgesic, antitussive, expectorant, and anti-inflammatory effects. And its clinical applications are treatmen...
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Chapter
Camptothecin
As an alkaloid derived from Camptotheca acuminata, camptothecin exerted its anticancer activity by specifically targeted topoisomerase I. The intolerable toxicity and poor solubility and stability in vivo of camp...
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Chapter
Allicin
Garlic is an edible and medicinal plant with a long history of application in China. Allicin is one of the main active substances of garlic, which has simple structure and is easy to be synthesized. It has a b...
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Chapter
Gastrodin
Gastrodin is extracted from Gastrodia elata, which is widely used for the treatment of vertigo, headache, neuralgia, neurasthenia syndrome, and brain traumatic syndrome. Studies showed that gastrodin has many pha...
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Chapter
Huperzine A
Huperzine A is obtained from Huperzia serrata, which is a highly effective and selective reversible inhibitor of acetylcholinesterase. It shows ability to improve learning and memory and was approved for treatmen...
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Chapter
Scopolamine
Scopolamine is a type of alkaloid from a variety of Solanaceae plants, which is the main active ingredient of these plants. It was first isolated from the Scopolia japonica, so named as scopolamine. Due to its ob...
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Article
Colorimetric glutathione assay based on the peroxidase-like activity of a nanocomposite consisting of platinum nanoparticles and graphene oxide
This work describes a colorimetric glutathione (GSH) assay that is taking advantage of (a) the peroxidase-like activity of a nanocomposite prepared from platinum nanoparticles and graphene oxide (PtNP/GO), (b)...
