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Article
Interferon response sequence potentiates activity of an enhancer in the promoter region of a mouse H–2 gene
The expression of class I transplantation antigens encoded in the major histocompatibility complex (H–2 in mouse, HLA in man) can be induced by α-, β- and γ-interferons1–5. Both transcriptional and post-transcrip...
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Article
Previous oral contraceptive use and breast cancer risk according to hormone replacement therapy use among postmenopausal women
To assess postmenopausal breast cancer risk in relation to particular patterns of oral contraceptive (OC) use according to hormone replacement therapy (HRT) exposure.
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Article
EPIC-Heart: The cardiovascular component of a prospective study of nutritional, lifestyle and biological factors in 520,000 middle-aged participants from 10 European countries
EPIC-Heart is the cardiovascular component of the European Prospective Investigation into Cancer and Nutrition (EPIC), a multi-centre prospective cohort study investigating the relationship between nutrition a...
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Article
Alcohol intake and breast cancer risk: the European Prospective Investigation into Cancer and Nutrition (EPIC)
Most epidemiologic studies have suggested an increased risk of breast cancer with increasing alcohol intake. Using data from 274,688 women participating in the European Prospective Investigation into Cancer an...
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Article
Unequal risks for breast cancer associated with different hormone replacement therapies: results from the E3N cohort study
Large numbers of hormone replacement therapies (HRTs) are available for the treatment of menopausal symptoms. It is still unclear whether some are more deleterious than others regarding breast cancer risk. The...
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Article
Menopausal hormone therapy and risk of ovarian cancer in the European prospective investigation into cancer and nutrition
The association between menopausal hormone therapy (HT) and risk of ovarian cancer was assessed among 126,920 post-menopausal women recruited into the European Prospective Investigation into Cancer and Nutriti...
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Article
Kinetic study of γ-hexabromocyclododecane orally given to laying hens (Gallus domesticus)
High concentrations of hexabromocyclododecane (HBCD) sometimes recorded in free-range hens' eggs are thought to be due to soil ingestion. Of the three stereoisomers of HBCD (α-, β-, and γ-HBCD), γ-HBCD is the ...
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Article
Open AccessAdiposity, hormone replacement therapy use and breast cancer risk by age and hormone receptor status: a large prospective cohort study
Associations of hormone-receptor positive breast cancer with excess adiposity are reasonably well characterized; however, uncertainty remains regarding the association of body mass index (BMI) with hormone-rec...
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Article
Menopausal hormone therapy and risks of colorectal adenomas and cancers in the French E3N prospective cohort: true associations or bias?
Menopausal hormone therapy (MHT) use has been quite consistently associated with a decreased colorectal cancer risk; however, data regarding adenomas, types of MHT, or tumour site are limited. We investigated ...
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Article
Open AccessReproductive factors and risk of hormone receptor positive and negative breast cancer: a cohort study
The association of reproductive factors with hormone receptor (HR)-negative breast tumors remains uncertain.
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Article
Exposure of ruminants to persistent organic pollutants and potential of decontamination
Human activities are emitting persistent organic pollutants (POPs) to the environment. These compounds have raised concerns about the risk of transfer through the food chain via animal products. They are chara...
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Article
Risk of breast cancer after stop** menopausal hormone therapy in the E3N cohort
Questions remain on how the excess risk of breast cancer associated with menopausal hormone therapy (MHT) evolves after treatment stops. We investigated that issue in the E3N cohort, with 3,678 invasive breast...
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Article
Erratum to: Risk of breast cancer after stop** menopausal hormone therapy in the E3N cohort
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Article
Chlordecone disappearance in tissues of growing goats after a one month decontamination period—effect of body fatness on chlordecone retention
Chlordecone (CLD) is an organochlorine pesticide whose extended use led to the contamination of at least 20 % of agricultural soils from the French West Indies. Livestock reared on polluted areas are involunta...
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Article
The impact of historical breastfeeding practices on the incidence of cancer in France in 2015
The purpose of the study was to estimate the number of new breast cancer cases in France in 2015 attributable to breastfeeding for durations below recommendations (at least 6 months per child), and cases preve...
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Article
Open AccessReceptor activator of nuclear factor kB ligand, osteoprotegerin, and risk of death following a breast cancer diagnosis: results from the EPIC cohort
Receptor activator of nuclear factor kappa-B (RANK)-signaling is involved in tumor growth and spread in experimental models. Binding of RANK ligand (RANKL) to RANK activates signaling, which is inhibited by os...
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Article
Use of benzodiazepines and cardiovascular mortality in a cohort of women aged over 50 years
To assess the association between use of benzodiazepines (including the Z-drugs zopiclone and zolpidem) and cardiovascular mortality in women aged over 50 years.
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Article
Open AccessRisk prediction for estrogen receptor-specific breast cancers in two large prospective cohorts
Few published breast cancer (BC) risk prediction models consider the heterogeneity of predictor variables between estrogen-receptor positive (ER+) and negative (ER-) tumors. Using data from two large cohorts, ...
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Article
Open AccessProspective analysis of circulating metabolites and breast cancer in EPIC
Metabolomics is a promising molecular tool to identify novel etiologic pathways leading to cancer. Using a targeted approach, we prospectively investigated the associations between metabolite concentrations in...
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Article
Open AccessDevelopment and validation of circulating CA125 prediction models in postmenopausal women
Cancer Antigen 125 (CA125) is currently the best available ovarian cancer screening biomarker. However, CA125 has been limited by low sensitivity and specificity in part due to normal variation between individ...
