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Article
Educational level and characteristics of invasive breast cancer: findings from a French prospective cohort
Breast cancer (BC) characteristics are known to influence patients survival. Social differences have been reported by previous studies for those characteristics but questions persist because of inconsistent co...
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Article
Lifestyle changes in middle age and risk of cancer: evidence from the European Prospective Investigation into Cancer and Nutrition
In this study, we aimed to provide novel evidence on the impact of changing lifestyle habits on cancer risk. In the EPIC cohort, 295,865 middle-aged participants returned a lifestyle questionnaire at baseline ...
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Article
Open AccessCirculating inflammatory biomarkers, adipokines and breast cancer risk—a case-control study nested within the EPIC cohort
Inflammation has been hypothesized to play a role in the development and progression of breast cancer and might differently impact breast cancer risk among pre and postmenopausal women. We performed a nested c...
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Article
Open AccessUse of systemic glucocorticoids and risk of breast cancer in a prospective cohort of postmenopausal women
Glucocorticoids could theoretically decrease breast cancer risk through their anti-inflammatory effects or increase risk through immunosuppression. However, epidemiological evidence is limited regarding the as...
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Article
Open AccessDietary intake of trans fatty acids and breast cancer risk in 9 European countries
Trans fatty acids (TFAs) have been hypothesised to influence breast cancer risk. However, relatively few prospective studies have examined this relationship, and well-powered analyses according to hormone recepto...
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Article
Control of poultry contamination in chlordecone-contaminated areas of the French West Indies
The consumption of private hold poultry foodstuffs, esca** of official maximum residue limit (MRL) controls in the commercial foodstuff, is an important exposure way for the local populations to chlordecone ...
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Article
Linear toxicokinetic of chlordecone in ewe’s serum
Chlordecone (CLD) is an organochlorine pesticide used in banana fields of the French West Indies between 1972 and 1993. This use resulted in a long-term pollution of soils and the possible contamination of far...
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Article
Evaluation of two contrasted activated carbon-based sequestration strategies to reduce soil-bound chlordecone bioavailability in piglets
Chlordecone (Kepone) (CLD) is a highly persistent pesticide formerly used in the French West Indies. High levels of this pesticide are still found in soils and represent a subsequent source of contamination fo...
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Article
Open AccessUse of nonsteroidal anti-inflammatory drugs and breast cancer risk in a prospective cohort of postmenopausal women
Although anti-inflammatory agents could theoretically have anticancer properties, results from cohort studies on nonsteroidal anti-inflammatory drugs (NSAIDs) and breast cancer (BC) risk are inconsistent.
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Article
Open AccessAdherence to the World Cancer Research Fund/American Institute for Cancer Research cancer prevention recommendations and risk of in situ breast cancer in the European Prospective Investigation into Cancer and Nutrition (EPIC) cohort
Even though in situ breast cancer (BCIS) accounts for a large proportion of the breast cancers diagnosed, few studies have investigated potential risk factors for BCIS. Their results suggest that some establis...
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Article
Open AccessDevelopment and validation of circulating CA125 prediction models in postmenopausal women
Cancer Antigen 125 (CA125) is currently the best available ovarian cancer screening biomarker. However, CA125 has been limited by low sensitivity and specificity in part due to normal variation between individ...
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Article
Open AccessProspective analysis of circulating metabolites and breast cancer in EPIC
Metabolomics is a promising molecular tool to identify novel etiologic pathways leading to cancer. Using a targeted approach, we prospectively investigated the associations between metabolite concentrations in...
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Article
Open AccessRisk prediction for estrogen receptor-specific breast cancers in two large prospective cohorts
Few published breast cancer (BC) risk prediction models consider the heterogeneity of predictor variables between estrogen-receptor positive (ER+) and negative (ER-) tumors. Using data from two large cohorts, ...
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Article
Use of benzodiazepines and cardiovascular mortality in a cohort of women aged over 50 years
To assess the association between use of benzodiazepines (including the Z-drugs zopiclone and zolpidem) and cardiovascular mortality in women aged over 50 years.
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Article
Open AccessReceptor activator of nuclear factor kB ligand, osteoprotegerin, and risk of death following a breast cancer diagnosis: results from the EPIC cohort
Receptor activator of nuclear factor kappa-B (RANK)-signaling is involved in tumor growth and spread in experimental models. Binding of RANK ligand (RANKL) to RANK activates signaling, which is inhibited by os...
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Article
The impact of historical breastfeeding practices on the incidence of cancer in France in 2015
The purpose of the study was to estimate the number of new breast cancer cases in France in 2015 attributable to breastfeeding for durations below recommendations (at least 6 months per child), and cases preve...
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Article
Chlordecone disappearance in tissues of growing goats after a one month decontamination period—effect of body fatness on chlordecone retention
Chlordecone (CLD) is an organochlorine pesticide whose extended use led to the contamination of at least 20 % of agricultural soils from the French West Indies. Livestock reared on polluted areas are involunta...
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Article
Erratum to: Risk of breast cancer after stop** menopausal hormone therapy in the E3N cohort
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Article
Risk of breast cancer after stop** menopausal hormone therapy in the E3N cohort
Questions remain on how the excess risk of breast cancer associated with menopausal hormone therapy (MHT) evolves after treatment stops. We investigated that issue in the E3N cohort, with 3,678 invasive breast...
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Article
Exposure of ruminants to persistent organic pollutants and potential of decontamination
Human activities are emitting persistent organic pollutants (POPs) to the environment. These compounds have raised concerns about the risk of transfer through the food chain via animal products. They are chara...
