16 Result(s)

Article

Preventing long-term disability in CIDP: the role of timely diagnosis and treatment monitoring in a multicenter CIDP cohort

Chronic inflammatory demyelinating polyneuropathy (CIDP) is an inflammatory disease affecting the peripheral nerves and the most frequent autoimmune polyneuropathy. Given the lack of established biomarkers or ...

Paula Quint, Christina B. Schroeter, Felix Kohle, Menekse Öztürk… in Journal of Neurology (2024)

Article

Correction to: Update on the diagnosis and treatment of neuromyelitis optica spectrum disorders (NMOSD) – revised recommendations of the Neuromyelitis Optica Study Group (NEMOS). Part II: Attack therapy and long-term management

Tania Kümpfel, Katrin Giglhuber, Orhan Aktas, Ilya Ayzenberg… in Journal of Neurology (2024)

Article

Update on the diagnosis and treatment of neuromyelitis optica spectrum disorders (NMOSD) – revised recommendations of the Neuromyelitis Optica Study Group (NEMOS). Part II: Attack therapy and long-term management

This manuscript presents practical recommendations for managing acute attacks and implementing preventive immunotherapies for neuromyelitis optica spectrum disorders (NMOSD), a rare autoimmune disease that cau...

Tania Kümpfel, Katrin Giglhuber, Orhan Aktas, Ilya Ayzenberg… in Journal of Neurology (2024)

Article

Update on the diagnosis and treatment of neuromyelits optica spectrum disorders (NMOSD) – revised recommendations of the Neuromyelitis Optica Study Group (NEMOS). Part I: Diagnosis and differential diagnosis

The term ‘neuromyelitis optica spectrum disorders’ (NMOSD) is used as an umbrella term that refers to aquaporin-4 immunoglobulin G (AQP4-IgG)-positive neuromyelitis optica (NMO) and its formes frustes and to a nu...

Sven Jarius, Orhan Aktas, Ilya Ayzenberg, Judith Bellmann-Strobl… in Journal of Neurology (2023)

Article

Somatosensory evoked potentials and magnetic resonance imaging of the central nervous system in early multiple sclerosis

Somatosensory evoked potentials (SSEP) are still broadly used, although not explicitly recommended, for the diagnostic work-up of suspected multiple sclerosis (MS).

Alexander Wuschek, Matthias Bussas, Malek El Husseini… in Journal of Neurology (2023)

Article

Cerebrospinal fluid lactate levels along the Alzheimer’s disease continuum and associations with blood-brain barrier integrity, age, cognition, and biomarkers

Cerebrospinal fluid (CSF) lactate levels have been suggested to be associated with disease severity and progression in several neurological diseases as an indicator of impaired energy metabolism, neuronal deat...

Paul Theo Zebhauser, Achim Berthele, Oliver Goldhardt… in Alzheimer's Research & Therapy (2022)

Article

Cerebrospinal fluid findings in COVID-19: a multicenter study of 150 lumbar punctures in 127 patients

Comprehensive data on the cerebrospinal fluid (CSF) profile in patients with COVID-19 and neurological involvement from large-scale multicenter studies are missing so far.

Sven Jarius, Florence Pache, Peter Körtvelyessy… in Journal of Neuroinflammation (2022)

Article

Cognitive impairment in early MS: contribution of white matter lesions, deep grey matter atrophy, and cortical atrophy

Cognitive impairment (CI) is a frequent and debilitating symptom in MS. To better understand the neural bases of CI in MS, this magnetic resonance imaging (MRI) study aimed to identify and quantify related str...

Christina Engl, Laura Tiemann, Sophia Grahl, Matthias Bussas… in Journal of Neurology (2020)

Article

Cytokine and immune cell profiling in the cerebrospinal fluid of patients with neuro-inflammatory diseases

Cytokines play multiple roles during neuro-inflammatory processes and several cytokines have been studied in the context of specific diseases. This study provides a comprehensive picture of cerebrospinal fluid...

Gildas Lepennetier, Zsuzsanna Hracsko, Marina Unger… in Journal of Neuroinflammation (2019)

Article

Update on the diagnosis and treatment of neuromyelitis optica: Recommendations of the Neuromyelitis Optica Study Group (NEMOS)

Neuromyelitis optica (NMO, Devic’s syndrome), long considered a clinical variant of multiple sclerosis, is now regarded as a distinct disease entity. Major progress has been made in the diagnosis and treatmen...

Corinna Trebst, Sven Jarius, Achim Berthele, Friedemann Paul… in Journal of Neurology (2014)

Article

CXCL13 is the major determinant for B cell recruitment to the CSF during neuroinflammation

The chemokines and cytokines CXCL13, CXCL12, CCL19, CCL21, BAFF and APRIL are believed to play a role in the recruitment of B cells to the central nervous system (CNS) compartment during neuroinflammation. To ...

Markus C Kowarik, Sabine Cepok, Johann Sellner… in Journal of Neuroinflammation (2012)

Article

Contrasting disease patterns in seropositive and seronegative neuromyelitis optica: A multicentre study of 175 patients

The diagnostic and pathophysiological relevance of antibodies to aquaporin-4 (AQP4-Ab) in patients with neuromyelitis optica spectrum disorders (NMOSD) has been intensively studied. However, little is known so...

Sven Jarius, Klemens Ruprecht, Brigitte Wildemann… in Journal of Neuroinflammation (2012)

Article

Anti-CD20 B-cell depletion enhances monocyte reactivity in neuroimmunological disorders

Clinical trials evaluating anti-CD20-mediated B-cell depletion in multiple sclerosis (MS) and neuromyelitis optica (NMO) generated encouraging results. Our recent studies in the MS model experimental autoimmun...

Klaus Lehmann-Horn, Eva Schleich, Deetje Hertzenberg… in Journal of Neuroinflammation (2011)