-
Article
Multiple sclerosis in the elderly: a retrospective cohort study
There is a lack of knowledge of disease course, prognosis, comorbidities and potential treatments of elderly MS patients.
-
Article
Open AccessLong-term outcome of natalizumab-associated progressive multifocal leukoencephalopathy in Austria: a nationwide retrospective study
The use of natalizumab (NAT) in multiple sclerosis (MS) may be complicated by progressive multifocal leukoencephalopathy (PML), a rare and life-threatening opportunistic brain infection. We aimed to analyze th...
-
Article
Open AccessEFAS/EAN survey on the influence of the COVID-19 pandemic on European clinical autonomic education and research
To understand the influence of the coronavirus disease 2019 (COVID-19) pandemic on clinical autonomic education and research in Europe.
-
Article
Prognostic performance of blood neurofilament light chain protein in hospitalized COVID-19 patients without major central nervous system manifestations: an individual participant data meta-analysis
To investigate the prognostic value of blood neurofilament light chain protein (NfL) levels in the acute phase of coronavirus disease 2019 (COVID-19).
-
Article
Open AccessA global view of comorbidity in multiple sclerosis: a systematic review with a focus on regional differences, methodology, and clinical implications
Multiple sclerosis (MS) is a chronic autoimmune disorder of the central nervous system which is associated with numerous comorbidities. These include cardiovascular disease, psychiatric and neurologic disturba...
-
Article
Open AccessBlood pressure characteristics in patients with acute basilar artery occlusion undergoing endovascular thrombectomy
Acute basilar artery occlusion (BAO) is a rare but potentially life-threatening neurological condition. While endovascular therapy (EVT) has been shown to improve outcome, there is limited knowledge about prog...
-
Article
Hypertrophic chronic pachymeningitis associated with Epstein-Barr virus reactivation: a case report
Hypertrophic pachymeningitis is a rare inflammatory condition characterized by the thickening of the dura mater. We describe a patient who presented with intractable headache and complex cranial nerve palsy. H...
-
Article
Open AccessContribution of Serum Lipid Profiles to Outcome After Endovascular Thrombectomy for Anterior Circulation Ischemic Stroke
The contribution of lipids, including low- and high-density lipoprotein cholesterol (LDL-C and HDL-C, respectively) and triglycerides (TG), to stroke outcomes is still debated. We sought to determine the impac...
-
Article
Open AccessMEsenchymal StEm cells for Multiple Sclerosis (MESEMS): a randomized, double blind, cross-over phase I/II clinical trial with autologous mesenchymal stem cells for the therapy of multiple sclerosis
Multiple sclerosis (MS) is an inflammatory disease of the central nervous system with a degenerative component, leading to irreversible disability. Mesenchymal stem cells (MSC) have been shown to prevent infla...
-
Article
Open AccessCerebrovascular manifestations of herpes simplex virus infection of the central nervous system: a systematic review
Intracerebral hemorrhage and ischemic stroke are increasingly recognized complications of central nervous system (CNS) infection by herpes simplex virus (HSV).
-
Article
Open AccessNeutrophil to lymphocyte ratio predicts intracranial hemorrhage after endovascular thrombectomy in acute ischemic stroke
The development of intracranial hemorrhage (ICH) in acute ischemic stroke is associated with a higher neutrophil to lymphocyte ratio (NLR) in peripheral blood. Here, we studied whether the predictive value of ...
-
Article
Open AccessSigmoid Sinus Characteristics Correlate with Early Clinical and Imaging Surrogates in Anterior Circulation Ischemic Stroke
Cerebral venous outflow may play a decisive role in acute ischemic stroke. Here, we assessed the relation of cerebral sinus vein characteristics with clinical and imaging surrogates of early outcome in acute i...
-
Article
Open AccessIdarucizumab in Dabigatran-Treated Patients with Acute Ischemic Stroke Receiving Alteplase: A Systematic Review of the Available Evidence
Current guidelines do not recommend the use of intravenous recombinant tissue plasminogen activator in patients with acute ischemic stroke who receive direct oral anticoagulants. While the humanized monoclonal...
-
Article
Open AccessAutoimmune Encephalitis at the Neurological Intensive Care Unit: Etiologies, Reasons for Admission and Survival
Early recognition and treatment of autoimmune encephalitis (AE) has become an essential issue in clinical practice. However, little is known about patients with deteriorating conditions and the need for intens...
-
Chapter
Using Classical Geostatistics to Quantify the Spatiotemporal Dynamics of a Neurodegenerative Disease from Brain MRI
We present a novel approach to characterize multiple sclerosis (MS) from brain magnetic resonance imaging (MRI) with geostatistics. Brain MRI provides excellent, exhaustive input data to geostatistical analysi...
-
Article
Open AccessFibrinogen consumption is related to intracranial clot burden in acute ischemic stroke: a retrospective hyperdense artery study
Understanding the underlying mechanism of thrombus formation and its components is critical for effective prevention and treatment of ischemic stroke. The generation of thrombotic clots requires conversion of ...
-
Article
Open AccessAbsence of CCR5 increases neutrophil recruitment in severe herpetic encephalitis
The neuroinflammatory response aimed at clearance of herpes simplex virus-1 (HSV-1) plays a key role in the pathogenesis of neuroaxonal damage in herpetic encephalitis. Leukocytes activated in an adaptive immu...
-
Article
Seizures and epilepsy in herpes simplex virus encephalitis: current concepts and future directions of pathogenesis and management
Mortality related to herpes simplex virus encephalitis (HSE) dropped dramatically with the systematic initiation of antiviral treatment in encephalitic syndromes. Further efforts need to be taken to reduce lon...
-
Article
Open AccessCXCL13 is the major determinant for B cell recruitment to the CSF during neuroinflammation
The chemokines and cytokines CXCL13, CXCL12, CCL19, CCL21, BAFF and APRIL are believed to play a role in the recruitment of B cells to the central nervous system (CNS) compartment during neuroinflammation. To ...
-
Article
Hyperacute Detection of Neurofilament Heavy Chain in Serum Following Stroke: A Transient Sign
Serological biomarkers which enable quick and reliable diagnosis or measurement of the extent of irreversible brain injury early in the course of stroke are eagerly awaited. Neurofilaments (Nf) are a group of ...
