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Article
Open AccessThe position of renal denervation in treatment of hypertension: an expert consensus statement
Hypertension is an important risk factor for cardiovascular disease. In the Netherlands, there are approximately 2.8 million people with hypertension. Despite treatment recommendations including lifestyle chan...
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Article
Open AccessThe challenge of choosing in cardiovascular risk management
Cardiovascular disease (CVD) is a major cause of morbidity and mortality worldwide. For many years guidelines have listed optimal preventive therapy. More recently, novel therapeutic options have broadened the...
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Article
PS11 - 3. Age, waist circumference and blood pressure are associated with skin microvascular flow motion in a healthy population: the Maastricht Study
Skin microvascular flow motion (SMF), i.e. blood flow fluctuation attributed to the rhythmic contraction and dilation of arterioles, is thought to play an important role in ensuring optimal delivery of nutrien...
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Article
P6.17: Pattern Between Arterial Stiffness, Blood Pressure and Age Observed in Individual Patients and Reference Population Explained by Biomechanics of Wall Remodelling
We recently found in patients that the pressure dependency of arterial stiffness is age-dependent, explaining clinically observed changes in stiffness with blood pressure (BP) lowering. Pulse wave velocity, BP...
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Article
P6.05: Pressure Dependency of Stiffness Differs with Age: Agreement Between Observations in Treated Hypertensives and the Reference Values for Arterial Stiffness Population
Arterial stiffness measures have a known dependency on actual blood pressure, requiring due consideration in risk assessment and treatment monitoring. Given the impact of age on arterial wall structural proper...
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Article
Open Access2.3 Clinically Applicable Approach to Discriminate Blood Pressure Dependent and Independent Changes in Arterial Stiffness
Monitoring of changes in arterial stiffness in hypertensive patients requires consideration of blood pressure (BP) dependent effects. Based on non-invasive measurements of carotid artery BP and cross-sectional...
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Article
Open AccessP6.17: Carotid Artery Cross-Sectional Area and Stiffness Non-Linearity as Markers of Vascular Ageing
Artery wall ageing involves elastic fibre loss and increased fibrosis, leading to dilatation and increased artery wall stiffness. Notably, the associated gradual transfer of tensile stresses from elastic to st...
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Article
Open AccessP9.11 Arterial Stiffness is Associated with Decreased Kidney Function in a Primary Care Population: Results from the Hippocrates-Study
Chronic kidney disease (CKD) is associated with cardiovascular morbidity and mortality. A common observation in both CKD and cardiovascular disease is increased arterial stiffness. Although many studies have f...
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Article
84 Prolonged Ventilation Causes P27KIP1 Induced Cell Cycle Arrest in Newborn Rat Lung
Background: In vitro studies have demonstrated that mechanical stretch can inhibit lung cell proliferation. This inhibition of cell growth may lead to reduction of alveolar formation and contribute to the develop...
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Article
Open Access1.2 Vascular Calcifications after Chronic Use of Vitamin-K Antagonists
Arterial calcification is commonly observed in cardiovascular disease and is associated with increased arterial stiffness, systolic hypertension and adverse cardiovascular outcome. Arterial calcification is an...
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Article
Open AccessDeterminants of DNA yield and purity collected with buccal cell samples
Buccal cells are an important source of DNA in epidemiological studies, but little is known about factors that influence amount and purity of DNA. We assessed these factors in a self-administered buccal cell c...
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Article
The contribution of six polymorphisms to cardiovascular risk in a Dutch high-risk primary care population: the HIPPOCRATES project
This study was designed to examine the contribution of six polymorphisms to the occurrence of cardiovascular disease (CVD) in a Dutch primary care population with a high prevalence of cardiovascular risk facto...
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Article
Open AccessP1.40 Determination of Pressure Independent Arterial Stiffness by Correcting Pulse Wave Velocity for Pressure-Area Relationship
Intrinsic (pressure independent) arterial stiffness is becoming increasingly important as treatment target in hypertensive patients but is still difficult to assess non-invasively. We measured pulse wave veloc...
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Article
Interactions between five candidate genes and antihypertensive drug therapy on blood pressure
Despite the availability of effective antihypertensive drugs, there is a large variation in response to these drugs. This study investigates whether polymorphisms in the angiotensin converting enzyme (I/D), an...
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Article
Ambulatory blood pressure, asymptomatic cerebrovascular damage and cognitive function in essential hypertension
Prolonged exposure to elevated blood pressure (BP) can lead to both structural (white matter lesions (WML) or infarctions) and functional changes in the brain. We studied in previously diagnosed essential hype...
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Article
C-reactive protein, atherosclerosis and kidney function in hypertensive patients
Previous studies have shown a relationship between coronary or carotid atherosclerosis and C-reactive protein (CRP) concentrations. In the present investigation, we evaluated the relationship between high-sens...
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Article
Renovascular disease in patients with hypertension: detection with duplex ultrasound
The aim of this study was to evaluate the accuracy of duplex ultrasound for the diagnosis of renovascular disease in a cohort of hypertensive patients. In 78 patients suspected of renovascular hypertension on ...
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Chapter
Genetics of Hypertension
High blood pressure is a common and major risk factor for cardiovascular disease. Still, the pathogenesis of essential hypertension remains incompletely understood. It is generally felt that different factors ...
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Article
Quinaprilat-Induced Vasodilatation in Forearm Vasculature of Patients with Essential Hypertension: Comparison with Enalaprilat
The aim of the present study was to assess the possible differences in hemodynamic and neurohumoral responses to local ACE inhibition in the human forearm of patients with essential hypertension with either qu...
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Article
What goes up, must come down: treating the hypertensive emergency
