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Article
Comparative Evaluation of the Pharmacological Activity of Fatty Aromatic Amides and Amines with a Framework Moiety and Their Non-Covalent Complexes
Pharmacological studies of the new fatty-aromatic amides, structural analogs of chlorobenzoylaminoadamantane (chlodantane), and non-covalent water-soluble complexes of chlodantane, adamantylbromophenylamine (b...
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Article
Complex Compounds Based on Pinostrobin Oxime
The article studied the structural features of solid dispersions of pinostrobin oxime with arabinogalactan, disodium salt of glycyrrhizic acid, polyvinylpyrrolidone and basic magnesium carbonate obtained by me...
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Article
Strategies for Solubility Enhancement of Anthelmintics (Review)
Most drug substances are poorly soluble in water so that their efficacies must be improved by increasing the dosage, which not only creates economic problems but also increases the toxicity of the future medic...
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Article
Effectiveness of Repeated Administration of Praziquantel with Disodium Glycyrrhizinate and Two Enantiomers of Praziquantel on Opisthorchis felineus (Rivolta, 1884)
Nowadays, it is still important to develop effective anti-opisthorchiasis agents. In this work, we tested a complex of praziquantel (PZQ) with a plant origin compound—disodium glycyrrhizinate—in the ratio 1:10...
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Article
Application of Natural Polysaccharides in Pharmaceutics
Modern data are presented on the pharmaceutical application of natural polysaccharides, such as pullulan, alginates, hyaluronic acid, dextrans, pectin, chitosan, and arabinogalactan, which are already actively...
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Article
Physicochemical Properties and Anti-Opisthorchosis Effect of Mechanochemically Synthesized Solid Compositions of Praziquantel with Glycyrrhizic Acid Disodium Salt
The mechanochemical preparation of solid compositions of praziquantel with plant saponin (glycyrrhizic acid disodium salt) is described. The study of a number of physicochemical parameters showed that dissolvi...
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Article
About the mechanism of membrane permeability enhancement by substances in their intermolecular complexes with polysaccharide arabinogalactan from larches Larix sibirica and Larix gmelinii
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Article
Physicochemical properties and anti-opisthorchosis effect of mechanochemically synthesized supramolecular complexes of Albendazole with the polysaccharide Arabinogalactan from Larix sibirica and Larix gmelinii
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Article
Pharmacological and physicochemical properties of mechanochemically synthesized supramolecular complexes of acetylsalicylic acid and polysaccharide arabinogalactan from lrches Larix sibirica and Larix gmelinii
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Article
Gel chromatographic and toxicological studies of the mechanochemical transformations of water-soluble polysaccharides
Changes in the molecular weight characteristics of polysaccharide macromolecules - arabinogalactan, hydroxyethyl starch 200/0.5, Fibregum, and dextrans 10, 40, and 70 - were studied during mechanochemical proc...
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Article
Efficient and safe medicines developed by Siberian scientists
Results of pharmacological and physico-chemical studies of supramolecular drug delivery systems on the basis of plant metabolites, viz. polysaccharides and glycyrrhizinic acid are summarized. The prospects of dev...
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Article
Antimicrobial activity of mechanochemically synthesized composites of antibiotics and nanostructured silicon dioxide
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Article
Mechanochemical preparation of water-soluble composites based on quercetin
The solubility and antioxidant activity of the bioflavonoid quercetin was increased from its mechanochemically prepared solid composites with metal carbonates and carbohydrate compounds.
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Article
Structural transformations of arabinogalactan from the Siberian larch during mechanochemical processing and the biological properties of the products
It has been found by gel-penetrating chromatography and quantitative 13C NMR spectroscopy that mechanochemical processing of arabinogalactan isolated from the wood of the Siberian larch changes the molecular mass...
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Article
Arabinogalactan, a plant polysaccharide, as a new tool for pharmacon clathration
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Article
Mechanical composites based on biologically active compounds from larch wood
Mechanical composites were prepared by mechanical chemical processing of a mixture of biologically active preparations of arabinogalactan (AG) and dihydroquercetin (DQ) isolated from larch wood. Their properti...
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Article
Mechanochemical preparation and pharmacological activities of water-soluble intermolecular complexes of arabinogalactan with medicinal agents
A possibility of mechanochemical preparation of water-soluble complexes of a plant polysaccharide arabinogalactan and poorly soluble medicinal agents (Sibazon(=Diazepam), Mezapam(=Medazepam), Indometacin, and ...
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Article
Solid-phase mechanochemical incorporation of a spin label into cellulose
Samples of cellulose labeled with stable nitroxyl radicals were prepared by mechanochemical synthesis. The samples were studied by IR and EPR spectroscopies, X-ray phase analysis, and electron microscopy. The ...
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Article
Pharmacological Activity of Complexes of Nonsteroidal Antiinflammatory Drugs with Glycyrrhizic Acid Obtained by Liquid- and Solid-State Synthesis
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Article
Synthesis and Evaluation of Ulcerogenic Activity of Instant Disperse Solid Systems Based on Acetylsalicylic Acid and Biologically Active Licorice Components