27 Result(s)
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Article
Open AccessAn explorative single-arm clinical study to assess craving in patients with alcohol use disorder using Virtual Reality exposure (CRAVE)—study protocol
Alcohol use disorder (AUD) belongs to the most burdensome clinical disorders worldwide. Current treatment approaches yield unsatisfactory long-term effects with relapse rates up to 85%. Craving for alcohol is ...
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Chapter
Case 24. Extranodal NK/T-Cell lymphoma, nasal type
NK/T-cell lymphomas are extremely rare lymphomas in the western world. The population of CD3+CD56+ NK/T-cells that seems to be the progenitor cells for those types of lymphomas is not homogeneous, which may ex...
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Article
Open Access(Neuro)therapeutic Approaches in the Field of Alcohol Use Disorders
Alcohol use disorder (AUD) is a burdening chronic condition that is characterized by high relapse rates despite severe negative consequences. There has been a recent emergence of interest in (neuro)therapeutic...
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Article
Clinical value of molecular subty** multiple myeloma using gene expression profiling
Using a data set of 1217 patients with multiple myeloma enrolled in Total Therapies, we have examined the impact of novel therapies on molecular and risk subgroups and the clinical value of molecular classific...
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Article
Open AccessThe flow cytometry-defined light chain cytoplasmic immunoglobulin index and an associated 12-gene expression signature are independent prognostic factors in multiple myeloma
As part of Total Therapy (TT) 3b, baseline marrow aspirates were subjected to two-color flow cytometry of nuclear DNA content and cytoplasmic immunoglobulin (DNA/CIG) as well as plasma cell gene expression pro...
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Article
Open AccessRenal insufficiency retains adverse prognostic implications despite renal function improvement following Total Therapy for newly diagnosed multiple myeloma
Renal insufficiency (RI) is a frequent complication of multiple myeloma (MM) with negative consequences for patient survival. The improved clinical outcome with successive Total Therapy (TT) protocols was limi...
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Article
Psychische Faktoren bei Magenbandimplantation
Adipositas ist eine weit verbreitete Krankheit in den westlichen Industrieländern, die hohe krankheitsbedingte Kosten verursacht. Verschiedene größere Studien konnten positive Effekte einer chirurgischen Adipo...
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Article
Differential expression of genes encoding tight junction proteins in colorectal cancer: frequent dysregulation of claudin-1, -8 and -12
As integral membrane proteins, claudins form tight junctions together with occludin. Several claudins were shown to be up-regulated in various cancer types. We performed an expression analysis of genes encodin...
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Chapter
Computerassistierte Rekonstruktion des vorderen Kreuzbandes mit dem SurgiGATE-System
Läsionen des vorderen Kreuzbandes (VKB) betreffen in erster Linie junge aktive Menschen [3, 10, 20]. Mit Zunahme der sportlichen Freizeitaktivitäten und Steigerung der Rasanz in vielen Sportarten steigt die Ve...
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Chapter and Conference Paper
What Information is Provided by the Human Genome?
Sequencing just the working draft of the entire human genome was technically an extremely challenging job, involving thousands of people working for over five years in six different countries. The competition ...
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Article
Advanced glycation end products induce choroidal endothelial cell proliferation, matrix metalloproteinase-2 and VEGF upregulation in vitro
Abstract
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Article
Frequent allelic loss of the BCL10 gene in lymphomas with the t(11;14)(q13;q32)
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Chapter and Conference Paper
Systematische Isolierung und Lokalisierung von Pankreas-Genkandidaten
Es wurden mehr als 200 Genkandidaten für das Pankreaskarzinom isoliert, die fast alle chromosomal zugeordnet werden konnten. Mehr als 60% sind neue Gene, die nicht homogen über die Chromosomen verteilt sind.
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Chapter and Conference Paper
Validation of Monitoring of Cerebral Oxygenation by Near-Infrared Spectroscopy in Comatose Patients
Secondary ischemic brain damage is a common event in patients with severe brain injuries, and is often verified at autopsy, for example, following severe head injury. It is widely accepted that secondary brain...
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Article
Solitary myeloblastoma presenting as acute hydrocephalus: review of literature, implications for therapy
An unusual presentation of a case of myeloblastoma (granulocystic sarcoma, chloroma) as demonstrated by computed tomography (CT) and selective angiography is reported. Our patient, who presented with acute hyd...
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Article
Validity and Reliability of Cardiac Output by CO2 Rebreathing
This article reviews the available literature on the validity and reliability of the non-invasive techniques, commonly known as CO2 rebreathing, for estimating cardiac output. The differing indirect methodologies...
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Article
LONG-TERM RESULTS OF BALLOON VALVULOPLASTY OF THE PULMONARY VALVE
The long-term efficacy of transluminal balloon valvuloplasty (val) was evaluated in 7 children (age 1.5-9.9 yrs) with pulmonary stenosis 1 yr post-val. Prior to, immediately (Imm) post-val and at 1 yr post-val...
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Chapter
Reversal of Vasoconstriction in the Isolated Perfused Rat Kidney by Picogram Amounts of PGE2
The isolated Krebs perfused kidney of the rat has previously been suggested to be unique among other species in that prostaglandin E2 (PGE2) and prostaglandin A2 (PGA2) produce vasoconstriction.1 This finding has...
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Chapter
Leisten-, Schenkel- und Nabelhernien. Rektusdiastase, Narbenhernien und seltene Bauchwandhernien (Spieghel-Hernie)
Die Operationsindikation für Leisten- und Schenkelbrüche konnte in den letzten zwei Jahrzehnten besonders auf das frühe Kindes- und hohe Lebensalter ausgedehnt werden. Eine gezielte Vorbereitung für Begleitkrankh...
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Article
119. Phimoseoperation und Beschneidung. Wann und wie soll operiert werden?
Prophylactic circumcision is not neceBary. In cases of circumcision on demand of the parents good results were obtained with Gomko's device, with the Plastibell method, and with oval subtotal circumcision. Rad...
