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Open AccessBiology of primary breast cancer in older women beyond routine biomarkers
There are numerous biomarkers which may have potential predictive and prognostic significance in breast cancer. This is extremely important in older adults, who may opt for less aggressive therapy. This work o...
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Correction to: KSR1 regulates BRCA1 degradation and inhibits breast cancer growth
A Correction to this paper has been published: https://doi.org/10.1038/s41388-021-01759-9
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Open AccessPatterns of biomarker expression in patients treated with primary endocrine therapy – a unique insight using core needle biopsy tissue microarray
Prediction of response to primary endocrine therapy (PET) in older women is based on measurement of oestrogen receptor (ER), progesterone receptor (PgR) and human epidermal growth factor (HER)-2. This study us...
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Open AccessThe OPTIMIZE patient- and family-centered, primary care-based deprescribing intervention for older adults with dementia or mild cognitive impairment and multiple chronic conditions: study protocol for a pragmatic cluster randomized controlled trial
Most individuals with dementia or mild cognitive impairment (MCI) have multiple chronic conditions (MCC). The combination leads to multiple medications and complex medication regimens and is associated with in...
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Open AccessThe significance of tumour microarchitectural features in breast cancer prognosis: a digital image analysis
As only a minor portion of the information present in histological sections is accessible by eye, recognition and quantification of complex patterns and relationships among constituents relies on digital image...
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Article
The Use of Figurative Language to Describe Frailty in Older Adults
Frailty affects 15% of non-institutionalized older adults in the United States, yet confusion remains in defining and, in turn, assessing frailty. Figurative language, such as metaphor, can help to explain dif...
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Article
Erratum: Equivalence of BCSH and WHO diagnostic criteria for ET
Correction to: Leukemia (2017) 31, 527–528; doi:10.1038/leu.2016.318; published online 29 November 2016 Following the publication of this article, the authors noted that the following acknowledgement needed to...
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Equivalence of BCSH and WHO diagnostic criteria for ET
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Impact of intratumoural heterogeneity on the assessment of Ki67 expression in breast cancer
In breast cancer (BC), the prognostic value of Ki67 expression is well-documented. Intratumoural heterogeneity (ITH) of Ki67 expression is amongst the several technical issues behind the lag of its inclusion i...
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JAK2V617F mediates resistance to DNA damage-induced apoptosis by modulating FOXO3A localization and Bcl-xL deamidation
The JAK2V617F mutation is found in most patients with a myeloproliferative neoplasm (MPN). This gain-of-function mutation dysregulates cytokine signaling and is associated with increased accumulation of DNA da...
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Markers of progression in early-stage invasive breast cancer: a predictive immunohistochemical panel algorithm for distant recurrence risk stratification
Accurate distant metastasis (DM) prediction is critical for risk stratification and effective treatment decisions in breast cancer (BC). Many prognostic markers/models based on tissue marker studies are contin...
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Open AccessKPNA2 is a nuclear export protein that contributes to aberrant localisation of key proteins and poor prognosis of breast cancer
It is recognised that modulations of the nuclear import of macromolecules have a role in changing cellular phenotypes and carcinogenesis. We and others have noticed that aberrant subcellular localisation of DN...
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KSR1 regulates BRCA1 degradation and inhibits breast cancer growth
Kinase suppressor of Ras-1 (KSR1) facilitates signal transduction in Ras-dependent cancers, including pancreatic and lung carcinomas but its role in breast cancer has not been well studied. Here, we demonstrat...
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Open AccessCheckpoint kinase1 (CHK1) is an important biomarker in breast cancer having a role in chemotherapy response
Checkpoint kinase1 (CHK1), which is a key component of DNA-damage-activated checkpoint signalling response, may have a role in breast cancer (BC) pathogenesis and influence response to chemotherapy. This study...
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Persistent STAT5 activation in myeloid neoplasms recruits p53 into gene regulation
STAT (Signal Transducer and Activator of Transcription) transcription factors are constitutively activated in most hematopoietic cancers. We previously identified a target gene, LPP/miR-28 (LIM domain containing ...
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Open AccessMARIMO cells harbor a CALR mutation but are not dependent on JAK2/STAT5 signaling
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Helix-loop-helix protein inhibitor of differentiation 4 (ID4) expression is an indicator of poor survival in Nigerian breast cancer women
This study investigates the prognostic features of helix-loop-helix protein inhibitor of differentiation 4 (ID4), a negative regulator of breast cancer-associated gene 1 (BRCA1) in breast cancer from Nigerian ...
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Open AccessNottingham Prognostic Index Plus (NPI+): a modern clinical decision making tool in breast cancer
Current management of breast cancer (BC) relies on risk stratification based on well-defined clinicopathologic factors. Global gene expression profiling studies have demonstrated that BC comprises distinct mol...
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Article
BET protein inhibition shows efficacy against JAK2V617F-driven neoplasms
Small molecule inhibition of the BET family of proteins, which bind acetylated lysines within histones, has been shown to have a marked therapeutic benefit in pre-clinical models of mixed lineage leukemia (MLL...
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Open AccessIdentification of key clinical phenotypes of breast cancer using a reduced panel of protein biomarkers
Breast cancer is a heterogeneous disease characterised by complex molecular alterations underlying the varied behaviour and response to therapy. However, translation of cancer genetic profiling for use in rout...
