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Article
Restraint Stress-Induced Expression of Fos and Several Related Genes in the Hypothalamus of Hypertensive ISIAH Rats
Stress can play a significant role in arterial hypertension and many other complications of cardiovascular diseases. Considerable attention is paid to the study of the molecular mechanisms involved in the body...
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Article
Genes Associated with Increased Stress Sensitivity in Hypertensive ISIAH Rats
Inherited stress-induced arterial hypertension (ISIAH) rats are characterized by increased stress reactivity of the hypothalamic–pituitary–adrenal and sympathoadrenal systems. The genetic basis of increased su...
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Article
Hypotensive Effects of Arginase Inhibition by L-Norvaline in Genetic Models of Normotensive and Hypertensive Rats
The main effect of arginase inhibition after administration of L-norvaline is a decrease in BP. At the same time, norvaline causes various side effects in normotensive and hypertensive animals. In our experime...
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Article
Genetic Control of the Behavior of ISIAH Rats in the Open Field Test
Genetic control of behavior in ISIAH rats with inherited stress-induced arterial hypertension in an open field test was investigated. Genome scanning (QTL analysis) was carried out in a group of male F2 hybrids (...
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Article
Arginine Metabolism in Hypertensive Rats under Arginase Inhibition by Norvaline
The hypotensive effect of arginase inhibition [1] can be achieved experimentally in two ways: by increasing the nitric oxide (NO) concentration that causes vasorelaxation, and/or by decreasing the circulating flu...
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Article
Genetic Polymorphism of Experimentally Produced Forms of Arterial Hypertension
The paper analyzes the distribution of polymorphic loci in rats of different hypertensive strains. When analyzing the transcribed loci of ISIAH rats and the corresponding loci of 11 other hypertensive strains/...
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Article
Antisense Oligonucleotides Immobilized on Silicon-Organic Nanoparticles as a Tool for Prolonged Correction of Hypertensive States
We propose an original method for controlling BP by administration of Si~ODN nanocomposites containing antisense oligonucleotides fixed on silicon-organic nanoparticles. ODN in nanocomposites are targeted to m...
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Article
The Biosocial Bases of Aggressivity and Aggressive Behavior
This review provides a brief exposition of the biosocial bases of the formation and expression of aggressivity in human society. The main watershed in scientific discussions on the nature of human aggression i...
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Article
Epigenetic Mechanisms of Blood-Pressure Regulation
The role of epigenetic mechanisms involved in blood-pressure regulation has been reviewed. It is known that some periods in early pre- and postnatal ontogenesis are very sensitive to some environmental and end...
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Article
Differential alternative splicing in brain regions of rats selected for aggressive behavior
Profiles of alternative mRNA isoforms have been determined in three brain regions of rats from an aggressive and a tame line selected for 74 generations. Among 2319 genes with alternatively spliced exons, appr...
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Article
Soluble epoxide hydrolase (sEH) as a potential target for arterial hypertension therapy
Using ISIAH rat strain, an animal model for stress-sensitive form of arterial hypertension, a comparison of the brain stem, hypothalamus, adrenal gland, and kidney transcriptomes for identification of the key ...
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Article
Increase in the concentration of sEH protein in renal medulla of ISIAH rats with inherited stress-induced arterial hypertension
The concentration of soluble epoxide hydrolase (sEH) protein was studied in renal medulla of adult rats from hypertensive ISIAH strain and normotensive WAG strain. The sEH is a key enzyme in metabolism of epox...
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Article
Toward gene therapy of hypertension: Experimental study on hypertensive ISIAH rats
TiO2-based nanocomposites were prepared to deliver oligonucleotides into cells. The nanocomposites were designed by the immobilization of polylysine-containing oligonucleotides on TiO2-nanoparticles (TiO2·PL-DNA)...
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Article
Strain-specific single-nucleotide polymorphisms in hypertensive ISIAH rats
Single-nucleotide polymorphisms (SNPs) in the coding and regulatory regions of genes can affect transcription rate and translation efficiency, modify protein function, and, in some cases, cause the development...
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Article
Differentially expressed genes in the locus associated with relative kidney weight and resting blood pressure in hypertensive rats of the ISIAH strain
The comparative full-genome sequencing of transcriptomes of the renal cortex and medulla from hypertensive ISIAH rats and normotensive WAG rats revealed the differential expression of genes in the locus of chr...
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Article
Parameters of Blood Flow in Great Arteries in Hypertensive ISIAH Rats with Stress-Dependent Arterial Hypertension
Magnetic resonance angiography was used to examine blood flow in great arteries of hypertensive ISIAH and normotensive Wistar rats. In hypertensive ISIAH rats, increased vascular resistance in the basin of the...
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Article
Brain metabolites in ISIAH and Wistar rats
Hypertension is one of the most common human diseases, which leads to serious disturbances, such as myocardial infarction and stroke. A decrease in the neuron viability in different parts of the brain in human...
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Article
Expression of catechol-O-methyltransferase (Comt), mineralocorticoid receptor (Mlr), and epithelial sodium channel (ENaC) genes in kidneys of hypertensive ISIAH rats at rest and during response to stress
Emotional stress plays a significant role in the processes of the development of arterial hypertension, especially in the presence of genetic predisposition. The origin and maintenance of hypertensive status d...
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Article
Aggressive behavior: Genetic and physiological mechanisms
The paper presents a review of the literature on the genetic determination of intraspecific aggressive behavior, one of the most complex and universal forms of social behavior in animals on different rungs of ...
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Article
The decreased expression of genes controlling the vascular tone in the kidneys of ISIAH rats with stress-induced arterial hypertension
The transcriptional activity of genes was studied in the kidneys of hypertensive ISIAH and normotensive WAG rats in order to detect genes significantly expressed in the kidneys of just one of the strains. Gene...
