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Article
Promising New Salt of Oseltamivir
A synthetic method for the promising new drug oseltamivir ethoxysuccinate is described in detail. Various conditions for obtaining the target substance are considered. Its complete physicochemical characterist...
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Article
Synthesis and Analgesic Activity of 4,10-Bis((±)-5-Benzoyl-2,3-Dihydro-1hpyrrolo[1,2-a]Pyrrole-1-Carbonyl)-2,6,8,12-Tetraacetyl-2,4,6,8,10,12-Hexaazatetracyclo[5,5,03,11,05,9]Dodecane
A method of preparing the potential analgesic substance 4,10-bis((±)-5-benzoyl-2,3-dihydro-1H-pyrrolo-[1,2-a]pyrrole-1-carbonyl)-2,6,8,12-tetraacetyl-2,4,6,8,10,12-hexaazatetracyclo[5,5,03,11,05,9]dodecane is des...
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Article
Nitrolysis of 2,6,8,12-tetraacetyl-4,10-dibenzyl-2,4,6,8,10,12-hexaazatetracyclo[5.5.0.03,11.05,9]dodecane
Nitrolysis of 2,6,8,12-tetraacetyl-4,10-dibenzyl-2,4,6,8,10,12-hexaazatetracyclo-[5.5.0.03,11.05,9]dodecane results in the substitution of benzyl groups by the nitro groups with the formation of 2,4,6,8,10,12-hex...
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Article
Management of flight control for “ExoMars-2018” robotic interplanetary space station
The article covers the current status of activities on development of “ExoMars-2018” robotic interplanetary space station in terms of SC Composite flight program, results of onboard systems interaction functio...
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Article
Features of RadioAstron Mission Control
Support means of the Spektr-R spacecraft flight and features of the Mission Control Center operation and spacecraft control are considered. Software for scheduling and preparing sessions of controlling and simula...
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Article
A search for raw materials for the isolation of shikimic acid
The content of shikimic acid in the vegetative parts of a number of plants growing in the Altai Territory has been studied. The greatest content of shikimic acid (about 1.5%) was found in the coniferous needle...
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Article
Principles of interaction of furazano-1,2,3,4-tetrazine-1,3-dioxide with organic solvents
Physicochemical interactions of furazano-1,2,3,4-tetrazine-1,3-dioxide (F) with organic solvents are studied according to thermogravimetry and UV spectrophotometry. It is shown that the donor-acceptor interact...
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Article
Facile method for the synthesis of oseltamivir phosphate
A ten-step scheme for the preparation of an antiviral agent, ethyl (3R,4R,5S)-4-acetylamino-5-amino-3-(pent-3-yloxy)cyclohex-1-enecarboxylate phosphate, from (-)-shikimic acid was studied. The main parameters of ...
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Article
Synthesis of Betulin Derivatives: N’{N-[3-OXO-20(29)-Lupen-28-OYL]-9-Aminononanoyl}3-Amino-3-Phenylpropionic Acid
A method for synthesizing N’-{N-[3-oxo-20(29)-lupen-28-oyl]-9-aminononanoyl}-3-amino-3-phenylpropionic acid, a compound that exhibited immunostimulating and antiviral activities, by adding the methyl ester of N-(...
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Article
Debenzylation of 2,6,8,12-tetraacetyl-4,10-dibenzyl-2,4,6,8,10,12-hexaazatetracyclo[5.5.0.03,11.05,9]dodecane
The debenzylation of 2,6,8,12-tetraacetyl-4,10-dibenzyl-2,4,6,8,10,12-hexaazatetra-cyclo[5.5.0.03,11.05,9]dodecane by catalytic hydrogenolysis in a mixture of HCOOH with other RCOOH (R = Me, Et, Pri) is accompani...
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Article
Behavior of [1,2,5]oxadiazolo[3,4-e][1,2,3,4]tetrazine 4,6-dioxide in various media
A behavior of [1,2,5]oxadiazolo[3,4-e][1,2,3,4]tetrazine 4,6-dioxide (1) in organic solvents and aqueous solutions of various acidity has been studied by UV spectrophotometry. Kinetic laws for the N,N′-dioxide 1 ...
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Article
Ferrous metallurgy in the German Democratic Republic