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Correction to: New clotting disorders that cast new light on blood coagulation and may play a role in clinical practice
The original version of the article unfortunately contained few errors.
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Heparin, coumarin, protein C, antithrombin, fibrinolysis and other clotting related resistances: old and new concepts in blood coagulation
The concept of resistance in blood coagulation has become important. In the past it was limited to the resistance shown by some patients to heparin, coumarin or aspirin. Subsequently, it was demonstrated that ...
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New clotting disorders that cast new light on blood coagulation and may play a role in clinical practice
Recently several variants of clotting factors have shown a peculiar behavior so that they appear as new defects. The factors involved are FII, FV and FIX. Prothrombin deficiency is usually associated with blee...
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Prethrombotic, prothrombotic, thrombophilic states, hypercoagulable state, thrombophilia etc.: semantics should be respected even in medical papers
The study of prothrombotic or thrombophilic states have drawn considerable attention during the past two decades. This was the result of the increasing number of thrombotic events, both arterial and venous rep...
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Comparative incidence of thrombosis in reported cases of deficiencies of factors of the contact phase of blood coagulation
Thrombotic manifestations occurring in patients with coagulation defects have drawn considerable attention during the last decade. It concerned mainly patients with hemophilia, vW disease or FVII deficiency. O...
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Associated prothrombotic conditions are probably responsible for the occurrence of thrombosis in almost all patients with congenital FVII deficiency. Critical review of the literature
The occasional occurrence of thrombosis in patients with congenital bleeding disorders has received considerable attention during the past decade. Myocardial infarction, ischemic strokes and venous thromboembo...
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Previous thrombosis-free pregnancies are no guarantee that subsequent oral contraception may also remain asymptomatic
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Arterial and venous thrombosis in patients with von Willebrand’s disease: A critical review of the literature
All patients with von Willebrand’s disease (vWD) who showed an arterial or venous thrombosis and were reported in the literature have been evaluated. 11 patients had arterial thrombosis while 19 had venous thr...
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Myocardial Infarction, Other Arterial Thrombosis and Invasive Coronary Procedures, in Hemaophilia B: A Critical Evaluation of Reported Cases
Myocardial infarction and other arterial thrombosis are commonly maintained to be rare in hemophilia patients. This, in general, seems true but the occurrence of a thrombotic event in hemophilia B is not excep...
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Pregnancies and Oral Contraceptive Therapy in Severe (Homozygons) FXII Deficiency: A Study in 12 Patients and Review of the Literature
Twelve women with severe Factor XII (FXII) deficiency were under observation for an average period of about 16 years. During this time, these women had 19 pregnancies without any bleeding or thrombotic complic...
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Long Term Use of Oral Contraceptives Without Thrombosis in Patients with FV Leiden Polymorphism: A Study of 37 Patients (2 Homozygous and 35 Heterozygous)
It is commonly accepted that women on oral contraceptive therapy have about a four fold increased incidence of venous thrombosis in comparison to non users. Women with FV Leiden polymorphism have an even highe...
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The Occasional Venous Thromboses Seen in Patients with Severe (Homozygous) FXII Deficiency are Probably Due to Associated Risk Factors: A Study of Prevalence in 21 Patients and Review of the Literature
According to our personal experience and to the study of the literature, 11 cases of venous thrombosis have been described as sporadic reports in patients with severe (homozygous) factor XII (FXII) deficiencie...
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Association of monoclonal gammopathy and polycythemia vera or essential thrombocythemia: study of a large cohort of patients
Concomitant cases of monoclonal gammopathies with polycythemia vera (PV) and essential thrombocythemia (ET) have been described. We report our experience in a large cohort of patients with ET and PV and the oc...
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Symptomatic Combined Homozygous Factor XII Deficiency and Heterozygous Factor V Leiden
A family with a combined deficiency of factor XII and factor V Leiden is presented. The proposita is a 72-year-old who showed a mild to moderate thrombotic tendency characterized by two episodes of deep venous...
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Antiplatelet glycoprotein autoantibodies in patients with autoimmune diseases with and without thrombocytopenia
The presence and specificity of antiplatelet autoantibodies in 32 patients with primary and 18 patients with secondary autoimmune thrombocytopenic purpura (AITP), as well as 11 nonthrombocytopenic patients wit...
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Different organization of von Willebrand factor oligomers in type-2A and -2B von Willebrand disease variants: effects of DDAVP infusion and protease inhibitors
Plasma von Willebrand factor (vWf) displays a complex pattern of repeating multimers, whose heterogeneous size distribution seems to depend on the proteolytic cleavage of the constituent vWf subunit. Smaller v...
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Detection of two missense mutations and characterization of a repeat polymorphism in the factor VII gene (F7)
The 3′ portion of the coagulation factor VII gene, containing the activation and serine protease domains, was investigated in four subjects with factor VII deficiency by temperature gradient gel electrophoresi...
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Effect of human recombinant erythropoietin on bleeding time, platelet number and function in children with end-stage renal disease maintained by haemodialysis
We studied platelet number and function in nine anaemic children with end-stage renal disease during a clinical trial with recombinant human erythropoietin (rHuEPO). All the children showed a correction in bot...
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Thrombocytosis in young people: Evaluation of 57 cases diagnosed before the age of 40
Over the past 13 years 57 cases of primary thrombocytosis in young people have been studied. Only patients with a platelet count over 500×109/liter and a follow-up longer than 2 years were considered. Thrombocyto...
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A frequent factor XII gene mutation in Hageman trait
An additionalTaqI restriction site was mapped in intron 2 of the factor XII gene. The site was found only in subjects with total or partial factor XII deficiency and thus represents the true gene lesion or a very...