37 Result(s)

Article

Comparative population structure analysis of Campylobacter jejuni from human and poultry origin in Bangladesh

Campylobacter jejuni is the most important cause of antecedent infections leading to Guillain–Barré syndrome (GBS) and Miller Fisher syndrome (MFS). The objective of the present study was...

Z. Islam, A. van Belkum, J. A. Wagenaar… in European Journal of Clinical Microbiology … (2014)

Article

A novel link between Campylobacter jejuni bacteriophage defence, virulence and Guillain–Barré syndrome

Guillain–Barré syndrome (GBS) is a post-infectious disease in which the human peripheral nervous system is affected after infection by specific pathogenic bacteria, including Campylobacter jejuni. GBS is suggeste...

R. Louwen, D. Horst-Kreft, A. G. de Boer… in European Journal of Clinical Microbiology … (2013)

Article

Blood–brain barrier dysfunction and recovery

In this paper we discuss the importance of the blood–brain barrier (BBB) as an interface between blood and brain. Many (brain) diseases change the functionality and integrity of the BBB. Mostly this results in...

A. G. de Boer, P. J. Gaillard in Journal of Neural Transmission (2006)

Chapter

Modulators of Blood-Brain Barrier (BBB) Permeability: In Vitro and in Vivo Drug Transport to the Brain

Transport to the brain is important for drugs that have their site of action in the brain compartment. However, drug transport to the brain is limited by the presence of various barriers in the brain. These co...

A. G. De Boer, P. J. Gaillard, I. C. J. Van Der Sandt… in Blood—Brain Barrier (2001)

Article

Dopamine release in the prefrontal cortex in response to memantine following sub-chronic NMDA receptor blockade with memantine: a microdialysis study in rats

Memantine is an uncompetitive N-methyl-D-aspartate receptor antagonist which blocks the NMDA receptor with moderate-affinity in a use- and voltage dependent manner. In clinical practice it is used chronically...

M. B. Hesselink, A. G. De Boer, D. D. Breimer, W. Danysz in Journal of Neural Transmission (1999)

Article

Adaptations of NMDA and dopamine D₂, but not of muscarinic receptors following 14 days administration of uncompetitive NMDA receptor antagonists

Behavioral changes have previously been reported following administrations of uncompetitive NMDA receptor antagonists memantine, amantadine and MK-801 for 14 days, at the doses that produce plasma levels comp...

M. B. Hesselink, A. G. De Boer, D. D. Breimer, W. Danysz in Journal of Neural Transmission (1999)

Chapter

Volume Regulation of the in Vitro Blood-Brain Barrier by Osmoreactive Amino Acids during Stress

The blood-brain barrier (BBB) is more permeable to blood-borne compounds during stress or disease. Moreover, during stress, an extra demand is put on the regulatory systems for the maintenance of cell volume. ...

P. J. Gaillard, A. G. De Boer, D. D. Breimer in Biology and Physiology of the Blood-Brain … (1996)

Article

The Use of Intracerebral Microdialysis for the Determination of Pharmacokinetic Profiles of Anticancer Drugs in Tumor-Bearing Rat Brain

Purpose. The use of intracerebral microdialysis as a tool to measure the penetration of anticancer agents in brain tumor was investigated.

E. C. M. de Lange, J. D. de Vries, C. Zurcher, M. Danhof… in Pharmaceutical Research (1995)

Article

Abstracts of papers and posters Biopharmacy and Phamaceutcal Technology Meeting

Spencer R. de Wijn, Wil E. Van den Hoven, David W. R. Hall… in Pharmacy World and Science (1993)

Article

Drug transport across the blood-brain barrier

This is the third part of a review on the transport of drugs across the blood-brain barrier. In the first two parts, the anatomical and physiological aspects and the various techniques that can be used to stud...

J. B. M. M. Van Bree, A. G. De Boer, M. Danhof, D. D. Breimer in Pharmacy World and Science (1993)

Article

Drug transport across the blood — brain barrier

This is part II of a review on the transport of drugs across the blood-brain barrier. In this part, the emphasis is on the various experimental techniques that can be used to characterize the blood — brain bar...

J. B. M. M. Van Bree, A. G. De Boer, M. Danhof, D. D. Breimer in Pharmaceutisch Weekblad (1992)

Article

Influence of food on the bioavailability of metoprolol from an OROS system; a study in healthy volunteers

The influence of food intake on the bioavailability of metoprolol from an OROS system has been investigated. No significant difference was found between OROS administration to fasting subjects or after breakfa...

G. van den Berg, F. van Steveninck… in European Journal of Clinical Pharmacology (1990)

Article

Improvement of drug absorption through enhancers

The application of enhancers for improvement of drug absorption via the nasal, transdermal and rectal route are outlined. The importance of the relation between the time course of the enhancing effect and the ...

A. G. de Boer, E. J. van Hoogdalem… in European Journal of Drug Metabolism and Ph… (1990)

Article

Transport of peptide and protein drugs across biological membranes

The transport characteristics of peptide and proteins drugs across various epithelial membrane barriers are outlines. These include transport through the intestinal, buccal, nasal and pulmonary absorptive muco...

J. C. Verhoef, H. E. Boddé, A. G. de Boer… in European Journal of Drug Metabolism and Ph… (1990)

Chapter

Improved Oral Peptide Delivery by Means of Mucoadhesion

Mucoadhesion implicates the possibility to achieve a very close contact between drug delivery system and biological membrane. This may increase the concentration gradient and also reduce the enzymatic degradat...

C.-M. Lehr, J. A. Bouwstra, J. J. Tukker, J. Verhoef, A. G. de Boer… in From Clone to Clinic (1990)

Article

Abstracts of papers Biopharmaceutical meeting

P. de Haan, A. P. Sam, H. L. G. M. Tiemeasen, H. E. Boddé… in Pharmaceutisch Weekblad (1989)

Article

Abstracts of papers Pharmacological meeting

H. H. G. Betendsen, C. L. E. Broekkamp, A. M. L. van Delft… in Pharmaceutisch Weekblad (1989)

Article

Rectal absorption enhancement of rate-controlled delivered ampicillin sodium by sodium decanoate in conscious rats

Because of the relatively poor intestinal absorption of ampicillin sodium, efforts have been made to enhance ampicillin absorption by co-administration of absorption promoters. In the present study the enhanci...

E. J. Van Hoogdalem, A. G. De Boer, D. D. Breimer in Pharmaceutisch Weekblad (1988)

Article

Abstracts of papers biopharmaceutical meeting

H. E. J. Hofland, J. A. Bouwstra, H. Talsma, F. Spies… in Pharmaceutisch Weekblad (1988)