21 Result(s)

Article

A Semi-Mechanistic Population Pharmacokinetic/Pharmacodynamic Model of Bortezomib in Pediatric Patients with Relapsed/Refractory Acute Lymphoblastic Leukemia

The pharmacokinetics (PK) of the 20S proteasome inhibitor bortezomib are characterized by a large volume of distribution and a rapid decline in plasma concentrations within the first hour after administration....

Julie M. Janssen, T. P. C. Dorlo, D. Niewerth, A. J. Wilhelm… in Clinical Pharmacokinetics (2020)

Article

Efficacy and toxicity of dexamethasone vs methylprednisolone—long-term results in more than 1000 patients from the Russian randomized multicentric trial ALL-MB 2002

A Karachunskiy, J Roumiantseva, S Lagoiko, C Bührer, G Tallen, O Aleinikova… in Leukemia (2015)

Article

Monitoring minimal residual disease in children with high-risk relapses of acute lymphoblastic leukemia: prognostic relevance of early and late assessment

The prognosis for children with high-risk relapsed acute lymphoblastic leukemia (ALL) is poor. Here, we assessed the prognostic importance of response during induction and consolidation treatment prior to hema...

C Eckert, N Hagedorn, L Sramkova, G Mann, R Panzer-Grümayer, C Peters… in Leukemia (2015)

Article

Prognostic value of genetic alterations in children with first bone marrow relapse of childhood B-cell precursor acute lymphoblastic leukemia

Despite risk-adapted treatment, survival of children with relapse of acute lymphoblastic leukemia (ALL) remains poor compared with that of patients with initial diagnosis of ALL. Leukemia-associated genetic al...

S Krentz, J Hof, A Mendioroz, R Vaggopoulou, P Dörge, C Lottaz, J C Engelmann… in Leukemia (2013)

Article

Favorable outcome in infants with AML after intensive first- and second-line treatment: an AML-BFM study group report

Infants <1 year of age have a high prevalence of prognostically unfavorable leukemias and a presumed susceptibility to treatment-related toxicities. A total of 125 infants with acute myeloid leukemia (AML) wer...

U Creutzig, M Zimmermann, J-P Bourquin, M N Dworzak, B Kremens, T Lehrnbecher… in Leukemia (2012)

Article

Autologous purified peripheral blood SCT in childhood low-risk relapsed ALL

The treatment of childhood B-cell-precursor ALL after isolated-extramedullary or late relapse is controversial. Most approaches are based on chemotherapy or allogeneic transplantation. The aim of this report i...

A Balduzzi, S Bonanomi, M G Valsecchi, G Gaipa, P Perseghin… in Bone Marrow Transplantation (2011)

Article

Complete remission after blinatumomab-induced donor T-cell activation in three pediatric patients with post-transplant relapsed acute lymphoblastic leukemia

R Handgretinger, G Zugmaier, G Henze, H Kreyenberg, P Lang, A von Stackelberg in Leukemia (2011)

Article

Standardized MRD quantification in European ALL trials: Proceedings of the Second International Symposium on MRD assessment in Kiel, Germany, 18–20 September 2008

Assessment of minimal residual disease (MRD) has acquired a prominent position in European treatment protocols for patients with acute lymphoblastic leukemia (ALL), on the basis of its high prognostic value fo...

M Brüggemann, A Schrauder, T Raff, H Pfeifer, M Dworzak, O G Ottmann, V Asnafi… in Leukemia (2010)

Article

Immunoglobulin and T-cell receptor gene rearrangements as PCR-based targets are stable markers for monitoring minimal residual disease in acute lymphoblastic leukemia after stem cell transplantation

H Kreyenberg, C Eckert, Y Yarkin, M Reising, A Willasch, R Handgretinger… in Leukemia (2009)

Article

Allogeneic hematopoietic SCT in children with ALL: current concepts of ongoing prospective SCT trials

The definition of indications for allogeneic SCT in children with high-risk (HR) ALL in the first remission or after the first or subsequent relapse depends on biological features, response to treatment and su...

A Schrauder, A von Stackelberg, M Schrappe, J Cornish… in Bone Marrow Transplantation (2008)

Article

Results of the first randomized multicentre trial on childhood acute lymphoblastic leukaemia in Russia

Until 1990, the survival of children with acute lymphoblastic leukaemia (ALL) in Russia was below 10%. To establish a protocol feasible under conditions there, ALL-MB 91 was designed to avoid prolonged bone ma...

A Karachunskiy, R Herold, A von Stackelberg, N Miakova, A Timakow, T Mahortih… in Leukemia (2008)

Article

Allogeneic haematopoietic stem cell transplantation in children with acute lymphoblastic leukaemia: the BFM/IBFM/EBMT concepts

Children with high risk or relapsed acute lymphoblastic leukaemia (ALL) can benefit from allogeneic haematopoietic stem cell transplantation (SCT). To reduce transplantation-associated complications, the BFM s...

C Peters, A Schrauder, M Schrappe, A von Stackelberg… in Bone Marrow Transplantation (2005)

Article

FLT3 mutations in childhood acute lymphoblastic leukemia at first relapse

S Wellmann, E Moderegger, A Zelmer, M Bettkober, A von Stackelberg, G Henze… in Leukemia (2005)

Article

Clinical significance of minimal residual disease in childhood acute lymphoblastic leukemia after first relapse

A von Stackelberg, K Seeger, G Henze, C Eckert in Leukemia (2004)

Article

Osteosarcoma after allogeneic bone marrow transplantation. A report of four cases from the Cooperative Osteosarcoma Study Group (COSS)

Osteosarcoma, one of the most frequent secondary malignancies after the treatment of young patients with cancer, has only very rarely been observed in association with hematopoietic stem cell transplantation (...

S S Bielack, J S Rerin, R Dickerhoff, D Dilloo, B Kremens… in Bone Marrow Transplantation (2003)