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Activation of GPR30 inhibits the growth of prostate cancer cells through sustained activation of Erk1/2, c-jun/c-fos-dependent upregulation of p21, and induction of G₂ cell-cycle arrest

G-protein-coupled receptor-30 (GPR30) shows estrogen-binding affinity and mediates non-genomic signaling of estrogen to regulate cell growth. We here showed for the first time, in contrast to the reported prom...

Q K Y Chan, H-M Lam, C-F Ng, A Y Y Lee, E S Y Chan, H-K Ng… in Cell Death & Differentiation (2010)