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  1. No Access

    Article

    HPV E6 degradation of p53 and PDZ containing substrates in an E6AP null background

    Human papillomavirus (HPV) type 16 and 18 E6 proteins target many of their cellular substrates for proteasome-mediated degradation. In the case of p53, this is mediated by the E6AP ubiquitin ligase. However it...

    P Massimi, A Shai, P Lambert, L Banks in Oncogene (2008)

  2. No Access

    Article

    HPV16 E6 confers p53-dependent and p53-independent phenotypes in the epidermis of mice deficient for E6AP

    High-risk human papillomaviruses are the causative agents of cervical and other anogenital cancers. In these cancers, two viral oncogenes, E6 and E7, are expressed. E6 is best known for its ability to inactiva...

    A Shai, M L Nguyen, J Wagstaff, Y-h Jiang, P F Lambert in Oncogene (2007)